tag:blogger.com,1999:blog-8964719845369935777.post6106762399926770092..comments2024-03-29T09:05:29.819-04:00Comments on Chemjobber: Process Wednesday: direct benzylation on scaleChemjobberhttp://www.blogger.com/profile/15932113680515602275noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-8964719845369935777.post-78631006946065027342013-02-06T23:59:48.368-05:002013-02-06T23:59:48.368-05:00I wonder to what happens to all the waste from all...I wonder to what happens to all the waste from all those new perfluoroalkylation and (almost-perfluoro)alkylation reactions, then, let alone all that TFA from peptide deprotections and HPLC runs? It's not like there's a facile way to remove it, unless you reduce the bejesus out of it, either electrochemically or with alkali metals (and that doesn't seem economical or compatible with the rest of the waste stream (such as the CH2Cl2 that probably comes along with the TFA).Hapnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-14227215072468218832013-02-06T13:42:07.368-05:002013-02-06T13:42:07.368-05:00Interesting paper and worth a read. Don't thi...Interesting paper and worth a read. Don't think the C-H activation was their first thought, but a very nice observation that 1) the ester seemed amenable to decarboxylation and 2) the decarboxylated substrate would be amenable to C-H activation. Good example of making lemonade out of lemons.<br /><br />The V-catalyzed NMO addition reaction is also interesting, especially the use of wiped-film evaporation to prepare the dehydrated NMO solution.<br /><br /> <br />What happens to waste on scale would make an excellent Process Wednesday topic. I always remember the shock I felt when I learned that the multiple drums of distillates, crystallization filtrates, and wet cake washes I'd generated for various processes went straight to the incinerator. My previously perceived carbon footprint was shattered that day. Kennoreply@blogger.com