tag:blogger.com,1999:blog-8964719845369935777.post8179158236756834241..comments2024-03-27T21:23:40.339-04:00Comments on Chemjobber: Process Wednesday: Oiling outChemjobberhttp://www.blogger.com/profile/15932113680515602275noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-8964719845369935777.post-47040930236500716532012-03-16T05:44:52.539-04:002012-03-16T05:44:52.539-04:00My beardMy beardAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-74322023782066019472012-03-15T01:57:43.121-04:002012-03-15T01:57:43.121-04:00seed crystals or cigarette smoke!seed crystals or cigarette smoke!Quintusnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-29999935529318786042012-03-15T01:10:41.792-04:002012-03-15T01:10:41.792-04:00If you don't have access to a superawesome cry...If you don't have access to a superawesome crystallization machine, what do you use?Chemjobberhttps://www.blogger.com/profile/15932113680515602275noreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-55360906227916468592012-03-14T23:32:00.044-04:002012-03-14T23:32:00.044-04:00I disagree. Crystallization is very much a scienc...I disagree. Crystallization is very much a science. A complex system of conditions can be controlled to give reproducible results. Finding the boundaries (other polymorphs) is risk-based. How many conditions should be screened? There is always the chance a new form will crop up, but due diligence, using Xtl16 and other screens/methods can reduce the chances of a new polymorph greatly. And its super important to get a good solubility curve at the beginning of the process development.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-27416456712101979802012-03-14T16:17:09.759-04:002012-03-14T16:17:09.759-04:00Sounds familiar - you hear the urban myths of crys...Sounds familiar - you hear the urban myths of crystallisations that have run on plant for years, then one day they make a dodgy batch of a different form, and that's all they can produce for ever more.<br /><br />It's surprising how wide the MSZW can be with some compounds - equipment like Avantium's Crystal 16 is useful for finding the boundaries. I'd be interested in alternative kit/methods used in other labs.LabMonkeyhttps://www.blogger.com/profile/00870695176070293582noreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-90315411129121871952012-03-14T11:13:40.264-04:002012-03-14T11:13:40.264-04:00Crystallisation is an art not a science. We moved ...Crystallisation is an art not a science. We moved into brand new labs once, nothing would crystallize. After around 12 months the compounds started to crystallise and would not stop after that! I had to re-write several procedures to cope with the new situation(s).Quintusnoreply@blogger.com