tag:blogger.com,1999:blog-8964719845369935777.post3431585541334056910..comments2024-03-27T21:23:40.339-04:00Comments on Chemjobber: A morning project management laughChemjobberhttp://www.blogger.com/profile/15932113680515602275noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-8964719845369935777.post-55203651911787617332012-12-04T08:33:14.733-05:002012-12-04T08:33:14.733-05:00Agree. Stick-and-ball models are a must. Not only ...Agree. Stick-and-ball models are a must. Not only in medicinal chemistry.DrFreddyhttp://syntheticremarks.comnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-39246458006581235192012-12-04T08:21:19.471-05:002012-12-04T08:21:19.471-05:00It's OK to be that guy! I even updated my post...It's OK to be that guy! I even updated my post accordingly, TYVM anonymous.<br /><br />No, but seriously, this is the part I love most about blogging; the never-ending and free of charge process of peer reviewing that happens in the comments.DrFreddyhttp://syntheticremarks.comnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-18101342070396908272012-12-03T17:02:34.227-05:002012-12-03T17:02:34.227-05:00this proves that medicinal chemists should have a ...this proves that medicinal chemists should have a decent model kit at hand and build their best active molecules so that they could hold them in their hand or put them on their bookshelf and stare at their shapes. Molecular modeling is all nice and quite easily available (PyMol) but the ease of connecting stick-and-ball atoms beats it, if the purpose is to get a qualitative idea about shape and ossible conformers/ My favorite (cheapo) alternative is HGS 5000 Biochemistry molecular model set, if you buy two sets. For more demanding (and richer) custommers the HGS7000 Stereochemistry set would be a good choice.<br /><br />(Way back when I was doing medchem I designed some rather selective and potent spiro compound series only because a molecular model gave me the idea about the preferred conformation of our lead compounds)milkshakehttp://orgprepdaily.wordpress.comnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-87280760620714123692012-12-03T16:27:10.348-05:002012-12-03T16:27:10.348-05:00They really isolated six stereoisomers? That has ...They really isolated six stereoisomers? That has to be the funniest part.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-13709889949839609922012-12-03T15:13:15.807-05:002012-12-03T15:13:15.807-05:00I think you want to say 8 or 4 stereoisomers. Or ...I think you want to say 8 or 4 stereoisomers. Or 4 or 2 SETS of enantiomers. I hate to be this guy, but it is a picky point that is fairly pervasive.Anonymousnoreply@blogger.com