tag:blogger.com,1999:blog-8964719845369935777.post5209590670453859136..comments2024-03-27T21:23:40.339-04:00Comments on Chemjobber: Process Wednesday: photooxidation to get industrial scale artemisininChemjobberhttp://www.blogger.com/profile/15932113680515602275noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-8964719845369935777.post-41582165349965740482014-03-08T19:57:02.949-05:002014-03-08T19:57:02.949-05:00Simply not true! Sanofi shared their results at Ar...Simply not true! Sanofi shared their results at Artemisinin Conferences and filed patents a few years before Seeberger's work. Sanofi is displeased about Max Planck Institute filing patents on what is essentially their chemistry applied to flow.<br /><br />You are also quite wrong about the Gates/ Sanofi partnership. Gates funded initial research into development of fermentation and chemical transformation of fermentation products to artemisinin. Sanofi benefited from this research but also needed to develop the chemistry described in this publication. Gates does NOT purchase any compounds - they support research. The Sanofi prices are actually comparable to natural sources. <br /><br />Sanofi is not blameless in the lack of increased access to anti-malarial treatments devolving from semi-synthetic artemisinin but it is ignorant to accuse them of pirating Seeberger's work and to suggest that Gates somehow profits from this!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-43940932666412936792014-03-08T16:46:23.477-05:002014-03-08T16:46:23.477-05:00@10:01 - I have a hard time understanding how anyo...@10:01 - I have a hard time understanding how anyone can belittle the terrific work of their chemistry colleagues. Critique is fine, but this comment is completely unprofessional and unwarranted. If a paper comes our improving on the synthesis, then great - we should always strive to improve, but an improvement would in no way detract from the good work that has come before. And I would like to see how the new chemistry is then implemented at scale - a synthesis is not a process. <br /><br />Really, your comment is way out of line. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-71652367789188027762014-03-07T10:01:38.148-05:002014-03-07T10:01:38.148-05:00I recently heard Peter Seeberger speak about this ...I recently heard Peter Seeberger speak about this work, which was originally developed in HIS lab (not Sanofi). The paper does mention this but only in passing. His latest work by which he makes the actual drug entities, all in flow, will be published shortly and dwarf this work allowing for the production of the compounds at a fraction of the cost. Sanofi is not thrilled about this.<br /><br />I also wanted to comment on the Gates/Sanofi partnership. The Gates foundation purchases the compounds "at cost" which is determined by Sanofi. The cost is typically 2-3 times higher than that of other vendors so one would ask - why wouldn't the foundation buy them from a cheaper source and help more people? The answer might come from the fact that the Gates foundation is a "significant share owner" of Sanofi, therefore any profit Sanofi makes is returned back to the foundation. The overlap of corporation and philanthropy is not always as well intentioned as depicted.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-21562443712868747802014-03-07T02:15:33.513-05:002014-03-07T02:15:33.513-05:00I always get a chuckle out of reading these things...I always get a chuckle out of reading these things, as I try to compare my own little microgram scale sodium bicarb/water washes with "720 L aqueous solution of sodium bicarbonate and was subsequently washed with 1440 kg water". I like to imagine a giant doing organic chemistry and carrying out these reactions.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-72003357793932148792014-03-06T17:10:11.569-05:002014-03-06T17:10:11.569-05:00Some days I do more web handling work than chemist...Some days I do more web handling work than chemistry, but photochemistry on coatings is huge because it's "clean". At least I like it because of that.Polychemhttps://www.blogger.com/profile/11318163213252728838noreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-78718521951981873392014-03-06T11:47:31.777-05:002014-03-06T11:47:31.777-05:00"...photochemical reactions are rarely practi...<i>"...photochemical reactions are rarely practiced in industry..."</i><br /><br />From the perspective of someone thinking that all chemistry happens in a kettle reactor, yes that is true, but they've been used in industrial coatings for decades and their use is growing. Sometimes your reactor is long, thin and wide, and maybe even moving. Johnhttps://www.blogger.com/profile/04412324900423436763noreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-49995453500376309492014-03-06T02:51:05.089-05:002014-03-06T02:51:05.089-05:00Really a great piece of work!Really a great piece of work!Paolonoreply@blogger.comtag:blogger.com,1999:blog-8964719845369935777.post-81857181221677954942014-03-05T14:27:12.673-05:002014-03-05T14:27:12.673-05:00This work is a tour de force - Sanofi has done a b...This work is a tour de force - Sanofi has done a brilliant job on a really important project. I saw this presented a couple of years ago at a Gordon - truly impressive stuff. My hat is off to the Sanofi Process team - Chapeau!Anonymousnoreply@blogger.com