Well, this was a boring and wild week. I hope that you had more of a boring week than my wild week, but hey, it's Friday and I am very much looking forward to this weekend. I hope you have a wonderful weekend, and I will see you on Monday.
Friday, June 13, 2025
"Unknown contaminant" (?) causes nitric acid tank release of NOX in Ohio
Via Ohio TV station WXIX, this chemical news:
VINTON COUNTY, Ohio (WXIX) - Residents in Vinton County are back in their homes after they were evacuated due to a chemical release at a southeast Ohio explosives manufacturing facility.
Emergency crews issued an evacuation order within a three-mile radius of the Austin Powder Red Diamond Company in McArthur Wednesday morning after a 5,000-gallon tank with nitric acid released 3,000 gallons of nitric oxide into the atmosphere.
According to the Ohio Environmental Protection Agency, an “unknown contaminant entered the nitric acid tank,” causing the chemical reaction to occur.
Although the release was stopped, the lingering chemical plume prompted an evacuation of the small Village of Zaleski and several roads surrounding the Austin Powder Plant. Residents were able to go home at 4:40 p.m.
I too do not know what the contaminant was, but I'm guessing it was water or air. No fun for the local birds for sure.
Thursday, June 12, 2025
Job posting: Director of Research & Development, ELANTAS North America, St. Louis, MO
Via ACS Chemistry Careers, this position:
ELANTAS North America is seeking a Director of Research & Development (R&D) to lead the creation, alignment, and execution of strategies for R&D programs, policies, and procedures. This role is based on-site in St. Louis, MO, and requires travel to other US facilities.
As a critical resource, the Director will collaborate with Global R&D teams and Business Line Directors to align development, lab testing, and technical services resources with business priorities.
Specific Responsibilities:
- Develops and recommends organization-wide technical research policies and programs needed to support profitable growth of the organization.
- Establishes & administers procedures pertaining to the discovery of new products, the alteration & improvement of existing products, and to the design of procedures and specifications of these products.
- Recommends budget requirements and takes action to guarantee effective research and development performance within approved budgets.
Requirements
Education & Experience:
- Ph.D. in Chemistry
- Minimum of 10 years related experience.
- Experience leading New Product Introduction (NPI) processes.
Via their website, this bit of info: "ELANTAS North America, Inc. is a premier global supplier of specialty resins for applications in the electrical and electronic industries." Best wishes to those interested.
Wednesday, June 11, 2025
Now I've seen it all: NJ municipal workers steal pool chemicals for their own business
SECAUCUS, NJ — On Tuesday, Secaucus Recreation Department employees John Schwartz, Frank Flanagan, Joseph Ferrara and Megan Wofsy-Flanagan were all arrested by Secaucus Police. All four are accused of stealing chemicals from the town pool and re-using them for their private pool maintenance business.
...Secaucus Police detectives used surveillance and undercover police officers to investigate. Police allege all four stole various pool chemicals purchased by the town and stored at the Secaucus town pool on Koelle Boulevard. Thefts sometimes occurred on a daily basis when these individuals were both on the clock and off the clock of the town’s payroll. They stole chemical amounts valued in the thousands, said police.
They would use the stolen chemicals to service pools for Crystal Clear Pool and Spa Management, said police, charging customers thousands of dollars. These private pools were located in Secaucus, but also in towns in Hudson, Bergen, Morris and Somerset counties. Also, some of these four town employees would work for their private company while getting paid on the clock by the town of Secaucus, allege police and the town.
Read the whole sorry article. I often joke with my management about the difficulty in fencing chemicals, but I guess I was wrong!
Tuesday, June 10, 2025
The 2026 Chemistry Faculty Jobs List: 4 research/teaching positions
The 2026 Chemistry Faculty Jobs List has 4 research/teaching positions.
Want to help out? Here's a Google Form to enter positions.
Don't forget to click on "load more" below the comment box for the full thread.
Are you having problems accessing the Google Sheet because of a Google Documents error? Email me at chemjobber@gmail.com and I will send you an Excel download of the latest sheet.
Monday, June 9, 2025
C&EN: "At Columbia University, chemical scientists are dismayed by funding cuts"
In this week's C&EN, this news (article by Aayushi Pratap):
...About 40 blocks north of Columbia’s main campus is the university’s Herbert Irving Comprehensive Cancer Center, located in the Washington Heights neighborhood. It’s the research home of Barry Honig, a professor of biochemistry and molecular biophysics who has spent over 4 decades as a researcher at Columbia studying protein interactions.
Honig was one of the collaborators on a project valued at over $1 million that lost its NIH grant. The group was investigating how proteins implicated in cancers interact with each other and the most effective ways to target them with drugs. “One day, the grant just didn't exist anymore—it is nothing like we have seen before,” he says. Columbia is currently in the process of negotiating the terms to restore the funding, he adds.
Honig says the research is fundamental to the field because scientists are only beginning to understand how proteins interact with each other. “We need this information to understand how drugs might bind to these proteins,” he says.
Looks like California is next. What a mess.
Friday, June 6, 2025
Have a great weekend
Well, this was a fun and busy week. Looks like things are going to get busier, but who knows. I hope that you had a great week and that you have a wonderful weekend. See you on Monday.
Thursday, June 5, 2025
Job posting: Scientist III, Process R&D, Thermo Fisher Scientific, Florence, SC
You will join a team of synthetic organic chemists to support the manufacturing of pharmaceutical ingredients at the Florence, SC - East site. Many of our products are already in the market, serving patients. We work on a variety of projects for existing and new clients. At this position, you will perform hands-on experimentation and learn knowledge and skills for process development of pharmaceutical products. We have a fast-paced working environment while keeping a good work-and-life balance. We encourage employees to participate in technical discussions.
Responsibilities:
- Develop chemical processes to synthesize drug intermediates and APIs that meet or exceed the quality requirements from clients.
- Collect process data through laboratory experiments with accurate, detailed documentation for process evaluation, development, and troubleshooting.
- Record and analyze scientific data/observations in detail. Summarize and interpret process data to draw conclusions. Write updates/reports. Participate in discussions with colleagues and clients.
Education: PhD in Chemistry or related discipline with commensurate experience
Experience: 0-2 years of experience
Full ad here. Best wishes to those interested.
Wednesday, June 4, 2025
RIP Robert Holton
Via the Tallahassee Democrat, this sad news:
Dr. Robert Anthony Holton, known as “Bob” to friends and colleagues, was a groundbreaking chemist and the scientist behind the first total synthesis of the cancer drug Taxol. He died peacefully at his home in Tallahassee, Florida, on May 21, 2025. He was 81.
Born in Fayetteville, North Carolina, and raised in Charlotte, he was the son of Marion Downing Holton and Aaron T. Holton. He met his first wife, Juanita Bird, at the University of North Carolina at Chapel Hill while earning his undergraduate degree in chemistry. They moved to Tallahassee, where he earned his doctorate from Florida State University and had their first son, Robert. After postdoctoral work at Stanford University, where their second son, David, was born, he held faculty positions at Purdue University and Virginia Tech. He returned to FSU in 1986 with his second wife, Dr. Marie E. Krafft, where they both held faculty appointments in the Department of Chemistry & Biochemistry and had their son, Paul. He spent the remainder of his career at FSU.
He is best known for his work on Taxol, a potent chemotherapy agent originally derived from the bark of the Pacific yew tree. The semisynthetic process he developed was the first commercially viable method for large-scale production. In 1993, he and his research group achieved the first successful total synthesis of Taxol, one of the most intricate and celebrated accomplishments in synthetic organic chemistry. His breakthroughs helped expand access to a critical cancer treatment and marked a milestone in the history of medicinal chemistry.
A teenage memory: hearing about the wonder drug Taxol, and then (while volunteering at a hospital) hearing one physician say to another: "I'm going to be on [local TV show] and they're going to ask me about Taxol - what should I say?"
A grad student memory: learning about the semisynthesis from 10-deacetylbaccatin III, and thinking "that's really cool."
A professional memory: learning about the facility in Michigan where the trees are grown for taxol synthesis, and thinking "that's really cool."
Rest in peace, Professor Holton.
Tuesday, June 3, 2025
The 2026 Chemistry Faculty Jobs List: 2 research/teaching positions
The 2026 Chemistry Faculty Jobs List has 2 research/teaching positions.
Don't forget to click on "load more" below the comment box for the full thread.
Are you having problems accessing the Google Sheet because of a Google Documents error? Email me at chemjobber@gmail.com and I will send you an Excel download of the latest sheet.
Monday, June 2, 2025
Is the generics market well-structured or poorly structured?
The United States has some of the lowest prices in the world for most drugs. The U.S. generic drug market is competitive and robust—but its success is not accidental. It is the result of a series of deliberate, well-designed policy interventions.
The 1984 Hatch-Waxman Act allowed generic drug manufacturers to bypass costly safety and efficacy trials for previously approved drugs by demonstrating bioequivalence through Abbreviated New Drug Applications (ANDAs). To spur competition, the Act also granted 180 days of market exclusivity to the first generic filer who challenges a brand-name patent—a mini-monopoly as a reward for initiative. Balancing static efficiency (P=MC) with dynamic efficiency (incentives for innovation) is hard, but Hatch-Waxman mostly got it right.The Generic Drug User Fee Amendments (GDUFA), modeled after the very successful Prescription Drug User Fee Act (PDUFA), require generic manufacturers to pay user fees to the FDA. These funds allow the Office of Generic Drugs to hire more staff and meet stricter approval timelines. GDUFA dramatically reduced ANDA backlogs and accelerated market entry, especially under GDUFA II.
He also mentioned the FDA’s Division of Policy Development in the Office of Generic Drug Policy, which was apparently helpful in accelerating generics to market.
Here's another viewpoint on a specific arm of the generics market, via an article in JAMA by Eli Cahan:
One family of drugs that has remained stubbornly susceptible to shortage is what experts call generic sterile injectables (GSIs). This class—which includes non–brand-name IV medications like fluids as well as many antibiotics and chemotherapies—accounts for a disproportionate share of the problem: between 2017 and 2023, 67% of all drugs in shortage were GSIs, according to data from IQVIA.
Part of the supply chain vulnerability derives from GSIs being less than enticing from the manufactures’ perspective, explained Erin Fox, PharmD, MHA, associate chief pharmacy officer at University of Utah.
An April 2025 report from the US Government Accountability Office (GAO) characterized “low price and low-profit margins” as key drivers of the GSI shortages. Late last year, a US Department of Health and Human Services (HHS) report likewise found that 70% of GSIs do not achieve profitability by 3 years. This limited upside has led to manufacturers exiting the market, according to the GAO report.
I think this is the core issue that isn't mentioned by Prof. Tabarrok - in some places, the generics market is genuinely neither competitive nor robust. Instead, there are not enough players in the market, the margins seem to be razor-thin, quality is lacking and the only profits to be made are in the times of shortage when prices spike. I am not saying that Prof. Tabarrok is wrong, but I think I am saying his praise is incomplete.
(In truth, I think Prof. Tabarrok is praising the policy responses from both Congress and the FDA for creating the correct conditions for the strengths of the American generics market and not the weaknesses...)
Friday, May 30, 2025
What if Harvard Chemistry were structured as a for-profit corporation?
Bloomberg's Matt Levine is a very fun financial writer, and this week's column as to how to avoid the new potential 21% endowment tax is hilarious.
In the current framework, a big capital gain is good, for the university. In a 21% excise tax framework, it is less good. (It’s 21% less good.) In the excise-tax framework, $100 of endowment income would pay for $79 of professors’ salaries. But if a for-profit corporation were to pay $100 of professors’ salaries, that payment would be tax-deductible (for the corporation). And so the trade is something like:
- The for-profit Chemistry Corporation hires all of Harvard’s chemistry professors, sets them up with labs, buys their equipment and pays their graduate students. Let’s say the operating budget of the chemistry department is $8 million, a number I just made up. The Chemistry Corporation takes over the responsibility for that budget.
- Harvard invests $100 million in the Chemistry Corporation and gets 95% of the stock; the professors get the rest.
- The Chemistry Corporation re-invests that cash with whoever currently manages Harvard’s endowment, targeting an 8% annual return.
- The Chemistry Corporation makes $8 million a year on its investments, and pays $8 million a year in operating expenses, for a net income of $0.
- It pays no taxes, because it has no net income.
- Harvard doesn’t pay any excise tax on the return on its $100 million Chemistry Corporation investment, because that return is zero.
- Harvard also rents office space to the Chemistry Corporation (not taxable, because not investment income?) and pays, you know, $1 a year for the Chemistry Corporation to provide teachers for undergraduate chemistry classes.
- I guess if they discover a valuable new chemical that’s gravy.
There is a precisely analogous approach for the Harvard Professional Football Team Inc., though it could also earn revenue from ticket sales. Or for the Classics Corporation, which probably couldn’t.
First of all, surely the Harvard chemistry department's annual budget is much more than $8 million. I'm guessing it's closer to $80 million, but university department finances are weird, especially since each professor can bring in their own money, etc, etc.
Second, I would be interested in hearing about the vague ratios of grant funds brought in versus startup package, and how those "ROIs" compare to 8% annual returns.
Large organizations seem to spend a lot of time working around tax avoidance, so it seems reasonable that if the US government began levying further excise taxes on endowments that universities would begin doing odd things to structure their finances to avoid them.
Have a great weekend
It would be nice if life slowed down just a little bit, but there you are. I hope that you had a calmer week than I did and that you have a great weekend. See you on Monday.
Thursday, May 29, 2025
Job posting: Senior Scientist, Medicinal Chemistry, Septerna, South San Francisco, CA
We are seeking a medicinal chemist to contribute to the chemistry efforts for one or more of our drug discovery programs working as part of a cross-functional team. Design of compounds, ability to execute synthesis within our internal laboratories, collaboration with CROs, and broad general chemistry department support will be key components of the position. This is an outstanding opportunity to learn from experienced medicinal chemists and drug hunters applying structure based-drug design, modern hit-identification strategies (including virtual screening and DEL), and advanced pharmacology, to GPCR targets to address unmet medical needs.
QUALIFICATIONS
This position requires a Ph.D. in organic chemistry with at least 3+ years of experience in a biotechnology or pharmaceutical setting. The successful candidate will have expertise in synthetic/medicinal chemistry. He/she will have experience in designing drug-like molecules and experience optimizing compounds towards drug development candidate selection. Experience with structure-based drug design is preferred.
Full ad here. Best wishes to those interested.
Wednesday, May 28, 2025
Xenon for mountain climbing?
Climbing Mount Everest typically takes weeks, with most of that time spent at the foot of the mountain adjusting to the thin air. But four British men last week shrank that timeline dramatically, traveling from London to the summit and back in less than a week, according to the organizer of their expedition.
They skipped the adjustment period, in part, by inhaling a secret weapon: xenon gas.
Their feat has roiled the world of mountaineering and prompted an investigation by the Nepalese government, as use of the gas is fiercely debated. Some research has shown that xenon can quickly acclimatize people to high altitudes, even as some experts say the benefits, if any, are negligible and the side effects of its use remain unclear.
Organizers said the gas was key to the speed of the climb, but their approach has prompted a broader debate that strikes at the core of mountaineering: Should scaling Mount Everest, one of sporting’s greatest accomplishments, be made easier — available to more people during a quick vacation — with the help of a performance enhancer?
Xenon, an odorless gas, has been known for years to activate a molecule called the hypoxia-inducible factor, which is also turned on when people acclimate to low oxygen, said Hugh Montgomery, a professor of intensive care medicine at University College London and a mountaineer who led an expedition to Mount Everest to study how humans respond to low oxygen.
“So what these people claim to have done,” he said, “is basically found a way to switch on the adaptation to low oxygen levels.”
The group took what was known from medical science, he said, “and have now applied it, recreationally, to sport mountaineering.”
Professor Montgomery said scientists were still unsure how xenon triggers this response.
This is pretty wild. I don't think this will change much of society (other than elite mountaineering) but I am curious if this will ultimately find applications in military scenarios.
Chemical plant explosion in Shandong province; 5 dead, 19 injured
An explosion at a chemical plant in Shandong province in eastern China on Tuesday has killed five people with a further six still missing, state broadcaster CCTV reported.
The explosion, which occurred at a site owned by Shandong Youdao Chemical in Gaomi city just before noon, also left 19 people injured.
The local emergency management bureau said on-site search and rescue operations and clean-up work had continued into the night.
The cause is yet to be determined.
The accident created a large fireball and sent clouds of smoke hundreds of metres into the air. Residents reported hearing a loud bang and said the blast had shattered the windows of many houses.
My sense is that this is one of the many thousands of smaller-scale (relatively speaking) chemical plants in China. Best wishes to the victims and their families.
Monday, May 26, 2025
Memorial Day; back tomorrow
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Philadelphia National Cemetery Credit: the Veterans Administration |
Back tomorrow.