To check further the speed of hydrolysis, tyrosine was synthesized by chloromethylating anisole, condensing it with methyl formamidomalonate and then heating with hydrobromic acid. In this preparation an ether cleavage was involved as well as hydrolysis and decarboxylation, but again the silver nitrate test was negative at the end of 60 minutes. Formamido compounds dissolve in hot hydrobromic acid in a few minutes as the formyl group comes off readily to form an amine salt. This rapid solution facilitates hydrolysis of the ester groups above that which would be found for acetamido or benzamidomalonates. As the average atmospheric pressure at the University of Colorado is about 630 mm. of mercury, solutions come to a boil at lower temperatures. As a result the length of time needed for hydrolysis may be less elsewhere.
Wednesday, March 16, 2022
Amusing way to end a short paper
The casualness at which older papers end is pretty amusing sometimes.