Thursday, May 2, 2024

Job posting: Principal Scientist, Medicinal Chemistry, San Diego, CA

Via friend of the blog Alex Goldberg, this job posting: 

Principal Scientist, Medicinal Chemistry

The successful candidate will lead lab chemistry efforts in the department enabling projects across the portfolio. They will also utilize the Genesis Therapeutics platform and assist medicinal chemistry efforts in drug discovery programs from Hit ID through candidate nomination. They will collaborate on multidisciplinary drug discovery projects, direct CRO chemists, and be responsible for synthetic chemistry strategy. The candidate will be expected to be a synthetic chemistry leader to drive programs.

Job Responsibilities:

  • Formulate and implement synthetic chemistry strategies across a portfolio to drive drug discovery programs from Hit ID through candidate nomination.
  • Identify opportunities to improve lab functions through technology, synthetic chemistry, or external resources.
  • Utilize the Genesis platform to execute drug discovery programs.
  • Use SBDD principles, optimize physiochemical properties, interpret in vitro and in vivo ADME/PK/Toxicology data, and understand in vitro and in vivo biology data to drive programs.
  • Work with other drug discovery disciplines (biology, DMPK, software engineers, computational chemists) to drive hypothesis driven decisions, improve the platform and contribute to the scientific excellence of the company.
  • Communicate and engage regularly with project team members.
  • Interact and direct a team of CRO chemists anywhere in size from 5-20.
  • Mentor internal chemists as well as other scientific disciplines on synthetic chemistry strategy.

Education and Experience Requirements:

  • PhD in synthetic organic chemistry or medicinal chemistry with at least 6 years of industrial drug discovery experience OR
  • MS in synthetic organic chemistry with at least 10 years of industrial drug discovery experience
Full ad here. Best wishes to those interested. 

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