Thursday, March 31, 2016

Phil Baran's thoughts on private versus public funding

Interesting to hear Phil Baran's thoughts on private funding and Elon Musk/SpaceX upon accepting honors from the American Academy of Arts and Sciences (an organization I have never heard of before). From his conclusion:  
Ladies and gentleman, society’s message to scientists is clear: simple curiosity is insufficient justification for our research. Scientists are great at thumping our chests and getting on our soap boxes about the importance of fundamental research. And, we are right. The problem is that nobody is listening.  
The average taxpayer has no idea what we do and the long-term benefits of basic science. Arguably, the public is more interested in the air pressure of a football than the atmospheric pressure on Mars. Moving forward, in addition to making the most of precious public funding and occasional philanthropy, perhaps we should follow Mr. Musk’s lead and turn to the private sector to help fund our own missions to Mars.
Obligatory wisecrack: I feel like I'm listening to David Drumlin in "Contact."

Two problems that I see: first, I don't think there's that much private funding to be had. Second, do we really want the US private sector driving US academic R&D research priorities? I believe in the ideals of the free market just as much as the next kid who grew up in suburbia in the US, but given the choice between research priorities being set by Presidential appointees and Congressional funding approval versus Wall Street, I just might choose the government. 

Wednesday, March 30, 2016

Afternoon fun: scientist fighting game

Madame Curie emits lots of alpha particles, I expect.
Credit: The Verge/ Superinteressante
As you can imagine, it's been a very busy day/week around here, but I did want to mention this super-cute "Scientist Kombat" game, for those of you who may have wasted an hour (or thousand) playing 2-D fighting games. (No game consoles in high school, but I loved Street Fighter and I definitely enjoyed a game of Tekken now and again in college.)

Seems that the Brazilian media site that is running this game has chosen Darwin, Hawking, Einstein, Tesla, Newton, Curie and Pythagoras of Samos. (click here to see gifs). Note that the browser game takes a very long time to load.

I sure would enjoy a historical "Chemist Kombat" game. Who would be the boss? Professor Corey and ability to project chiral oxazaborolidine-coordinated hydrides would be challenging.


Tuesday, March 29, 2016

Job posting: Associate Scientist/Scientist/Sr. Scientist, Pasadena, CA

From the inbox, a position at Protomer Solutions, a company in Pasadena, CA: 
Protomer Technologies is seeking to fill a position in our new and rapidly growing biotechnology company. We are looking for people who are passionate about biotechnology and improving the world through cutting edge bio-chemical research and technology development. We are a biotechnology company dedicated to alleviating and addressing diabetes through novel bio-engineering and glucose-responsive treatments. 
Desired education and experience level: BS, MS and/or PhD with 0+ years of experience. Compensation and position varies depending on experience level.
Ability to work in molecular biology or chemistry laboratory is a must for all levels. Scientist level position requires expertise in one of: peptide chemistry, protein chemistry or molecular biology. Additional demonstrated expertise in protein engineering is a plus. 
Sr. Scientist requires MS with 5+ or PhD with 3+ years experience. We will consider all applicants with any level of experience and complementary skills. 
Please send your CV directly to contact@protomer.com.
Here's a little media tidbit about them. Best wishes to those interested.  

Monday, March 28, 2016

Job posting: senior chemical safety specialist, Argonne, IL

From the inbox, a position at Argonne National Laboratory:
Position Description  
Establishes and leads the Argonne National Laboratory process related to chemical safety, with special emphasis and focus on reactive chemistry. Plans and executes tasks to ensure implementation of the chemical safety program and prime contract stipulated requirements. This is expected to include development of appropriate controls to ensure that work is safely and effectively controlled to the extent possible to minimize risk. At the Directorate and division level, serves as a technical resource for implementation of chemical safety programs to meet contract and regulatory requirements. This may include participating on work plan reviews and development of tools to aide in the evaluation of reactivity hazards to be integrated with the Laboratory`s existing work planning and control processes. Serves as a resource in the development and education of Argonne personnel as related to chemical safety program/process requirements. Provide consultation for the disposition and removal of chemical waste. 
Position Requirements 
  • Master's Degree and 8+ years work experience or equivalent.
  • Comprehensive knowledge of chemical safety program development and implementation, to include reactive chemistry, at laboratory or high hazard facilities; corporate chemical safety policies and requirements; exposure assessments; exposure controls; training; and program appraisal.
  • Comprehensive skill and experience in analysing chemical reactivity hazards and developing and implementing work controls....
There is more at the link. If you're interested in applying and would like to talk to the hiring manager, contact me (chemjobber@gmail.com) and I can put you in touch with them. 

Is it a big deal to switch from Fortran to C++ and Python?

The article about a computational comeback in drug discovery was a good read (C&EN, Jan. 25, page 19). I do agree that graphics processing unit (GPU) technology has made computer calculations faster in drug design. Using GPU technology in conjunction with advanced computer languages is really how the computer systems work. 
One benefit to computer modeling is using scientific computer languages such as C++ and Python, which have made the calculations of advanced chemical mathematics much faster. Previously, the use of the Fortran language was acceptable for chemical math equations that were simplified. Continued advancement in computer hardware and languages will spur growth for future years. 
Mike Renier
South Range, Mich.
I wish I could comment intelligently on this, but I can't.  

This week's C&EN

A few articles from this week's C&EN:
*fixed - thanks, uncle sam! 

Sunday, March 27, 2016

What is the smell of TATP?

First, my condolences to anyone who is living in the Brussels area. These bombings are terrible. From a New York Times article (by Andrew Higgins and Kimiko de Freytas-Tamura) about the terrorists' preparation of the explosive triacetone triperoxide, an interesting detail: 
...Mr. Rodrigues said that Ibrahim and Khalid el-Bakraoui were his first tenants, and that they had provided him with fake identity papers and bogus pay slips to obtain a one-year lease. Three others, including a man since identified as Mr. Laachraoui, visited regularly. 
The smell in their apartment was horrendous, the owner said, recalling how he had seen on the floor two large fans similar to ones found on construction sites, and an exhaust fan on the wall. Such fans would be useful in the final stages of preparing TATP, the homemade peroxide-based explosives used in the bombings on Tuesday, and also by the November suicide bombers in Paris. 
After breaking into the apartment on Tuesday morning, police officers found 30 pounds of TATP — enough for another powerful bomb — as well as nearly 40 gallons of acetone and eight gallons of hydrogen peroxide, materials used in producing TATP. They also found a suitcase full of nails and metal bolts, used to make bombs more lethal, as well as an Islamic State flag. 
Mr. Rodrigues said that whenever he visited the apartment, the door to the living room was always shut, while windows throughout the apartment were always open. Mr. Rodrigues said he would smell a “very strong chemical odor” that he could not quite put a finger on. “If it smelled like bleach or drugs, I would’ve recognized it,” he said....
OK, I know what acetone smells like, and I know what 50% hydrogen peroxide smells like. Do they really smell so bad? I like the smell of acetone, and 50% hydrogen peroxide just smells sour-ish to me. Here's NYT correspondent C.J. Chivers on Twitter:
TATP production often involves multiple distinct odors, at different stages. Sounds like odors were noted, no one acted. 
So I am not asking anyone to give me a detailed treatise on the making of TATP (although I seem to recall one (ok, just a simple synthetic procedure) in JACS a few years back), but what's the smell of making TATP? 

Friday, March 25, 2016

The View from Your Hood: Seoul, South Korea

Total synthesis, Snowy Seoul, South Korea
Anonymous submission.

(got a View from Your Hood submission? Send it in (with a caption, please) at chemjobber@gmail.com; will run every other Friday.)


Job posting: research associate, 0-5 years, Gilead Sciences, Seattle, WA; also summer intern position

As Research Associate, you will participate in an integrated research team aimed at discovering and synthesizing novel chemical entities for various targets. Under the guidance of an experienced Research Scientist you will be responsible for planning, designing and executing multi-step synthesis pathways toward key target molecules, followed by purification and compound characterization. Communication of results, methods and conclusions to departmental colleagues is essential. Collaboration with colleagues across disciplines, participation in project team meetings, and contribution toward creative problem solving are all encouraged. 
BS or MS in Organic/Medicinal Chemistry
Familiarity with modern chromatographic techniques, including LCMS, flash chromatography and preparative scale HPLC highly preferred.
Familiarity with modern analytical techniques (NMR, IR etc).
A strong interest in medicinal chemistry combined with good laboratory skills
Familiarity with MS Office and ChemDraw required.
Essential: BS degree in Chemistry with no industry experience.
Best wishes to those interested.

UPDATE: Also, a summer intern position at the same Gilead site in Seattle. 

Thursday, March 24, 2016

Daily Pump Trap: 3/22/16 edition

A few of the positions posted on C&EN Jobs:

Hanover, NH: Avitide is looking for a Ph.D. biochemist to work on purification of biological molecules.

Zeroes!: Seattle Genetics (Bothell, WA) is looking for a B.S. chemist (0-4 years experience) to perform bioconjugation chemistry.

Cambridge, MA: Gen9 is seeking a Ph.D. "synthetic DNA chemist"; 5 years industry experience desired

Indianapolis, IN: Heritage Research Group appears to be involved somehow with asphalt chemistry? They're looking for a chemist/industrial hygienist.

Chicago Heights, IL: The Thorn Creek Basin Sanitary District seeks a chemist/laboratory supervisor. "Expected to respond to emergencies 24 hours per day, 7 days per week."

Water chemistry jobs up? (doubtful): The Massachusetts Water Resources Authority (Southborough, MA) is looking for a M.S./Ph.D. program manager for chemistry. Not often you see a water organization looking for a Ph.D. chemist; 84,800.00 - 114,900.00 offered.

Berkeley, CA: This Lawrence Berkeley National Laboratories position is fascinating:
Berkeley Lab’s Material Sciences Division (MSD) has an opening for a Divisional Communications Lead. You will provide a full range of comprehensive scientific and technical communication functions to support MSD's research.
M.S. in science, 5 years of experience of research/science communications experience desired.

"Canada": The National Research Council of Canada is looking for a Ph.D. physical scientist to perform optical research. "From $49,670 to $140,418 per annum": a broad range.

Ivory Filter Flask: 3/22/16 edition

A few of the academic positions posted at C&EN Jobs this past week:

Not too many faculty positions recently: Probably not a surprise in March. At some point here, we'll start seeing ads for the Last Minute Lecturer.

Urbana, IL: Speaking of which, UIUC is looking for two organic/general chemistry lecturer/instructors to start as early as May.

Galesburg, IL: Knox College looking for a fall sabbatical replacement; general/organic chemistry instruction desired.

Baltimore, MD: Biology-ish postdoc at Johns Hopkins - what the heck is "molecular engineering?"

Also...: Time-resolved spectroscopy post-doc at UIUC. 

Wednesday, March 23, 2016

Mental health survey for graduate students and postdocs

Via Twitter (and one of the co-investigators), a survey about mental health for graduate students and postdocs: 
Dear Graduate Students and Postdoctoral Fellows: 
All Master's and PhD students and postdoctoral fellows from all disciplines are invited to participate in a research study that aims to measure the prevalence of anxiety, depression, stress, and burnout in the graduate student and postdoctoral fellow population. Through this study, you will be asked to confidentially respond to a series of questions via an online study questionnaire. Although you may not get immediate personal benefit from taking part in this research study, your responses may help improve the level of understanding of these issues in this population and thus help establish the need for developing programs and resources to address these measured issues. All participants will be entered into a drawing for the chance to win one of several prizes including an iPad, Kindle, or a gift card ranging in value from $25-$100.  
Of course, you have a choice about whether or not to complete the questionnaire. If you do participate, you are free to skip any questions or discontinue at any time. If you desire, you may receive the results of this study when it is completed.
Interested? The survey is here.  

Tuesday, March 22, 2016

This week's C&EN

A few stories from this week's Chemical and Engineering News: 

Sunday, March 20, 2016

EdX class in medicinal chemistry

From the inbox, Professor Erland Stevens of Davidson College is once again teaching his class on medicinal chemistry:
I teach a free, online course in medicinal chemistry on the edX platform.  The course was developed at Davidson College and is currently offered through a collaboration with Novartis.  In three previous iterations, the course has attracted over 30,000 registrants from around the world.  The course repeats on Monday, March 21st.

The course runs 7 weeks and covers topics ranging from pharmacokinetics (Vd, clearance, half-life), metabolism, activity against drug targets (Ki, Kd, IC50), lead discovery (screening, filtering hits), and lead optimization.  The target audience for the course includes chem/bio/pharmacy graduate students, very recent hires in pharma, or anyone looking for an introduction into topics relevant to drug discovery.
Sounds interesting!  

Saturday, March 19, 2016

Postdoc loses arm in lab explosion in Hawaii

I was first alerted of this via the Division of Chemical Health and Safety's listserv; it has only gotten worse. From Hawaii News Now (the website of the three Honolulu television stations), the story: 
MANOA, OAHU (HawaiiNewsNow) - Officials say the 29-year-old researcher seriously injured in an explosion at a University of Hawaii lab Wednesday was conducting a routine experiment and handling relatively stable compounds when something went very wrong. 
"Something happened out of the ordinary and we don't know what that is yet," Brian Taylor, dean of UH-Manoa's School of Ocean and Earth Science and Technology, told reporters at a news conference Thursday. 
Post-doctoral fellow Thea Ekins-Coward lost an arm and suffered other injuries in the explosion, which happened about 6 p.m. Wednesday in a basement lab at the Pacific Ocean Sciences and Technology Building. 
 On Thursday, engineers determined the building where the explosion occurred remains structurally sound, and employees and students will be allowed to return Friday.
The university is reviewing its protocols and safety procedures in the wake of the explosion, and reaching out to experts nationally for assistance on the investigation. 
Ekins-Coward was conducting a routine experiment -- something that had been done every day since 2008 -- when the explosion happened in the Hawaii Natural Energy Institute lab, UH officials said. They said she was working with hydrogen, oxygen and carbon dioxide...
The morning news reports were pretty bad, but I didn't understand why the Chancellor of the school decided to hold a press conference (with the EH&S director telling us all about Dr. Ekins-Coward's safety training from the university) until I saw the above news report that she has been quite seriously injured.

Twitter report from Hawaii prof. Hope Jahren on the story. 

WWWTP: Czech academia edition

Credit: Anonymous reader
From the inbox, a reader comments: "This is an ad for vscht, a chemistry school in Prague, Czech Republic, one of the most prestigious and big in central Europe. They just ran an ad campaign featuring 2 pentavalent carbons."


Daily Pump Trap: 3/18/16 edition

A few of the positions posted on C&EN Jobs this past week:

Cambridge, MA: Another Moderna position, this one in analytical development.

Morgantown, WV: Mylan Therapeutics is looking to hire a senior QC chemist (B.S. degree, 4-6 years experience desired.) I like the request for "consensus gathering skills."

A broader look: Monster, Careerbuilder, Indeed and USAjobs.gov show (respectively) "1000+", 431, 10,863 and 0 positions for the search term "chemist." LinkedIn shows 2134 positions for the job title "chemist", with 216 for "analytical chemist", 33 for "research chemist", 44 for "medicinal chemist", 25 for "organic chemist" and 6 for "synthetic chemist."

Irvine, CA: Allergan looking for a B.S./M.S. chemist.

South San Francisco, CA: Reset Therapeutics, looking for a B.S./M.S./Ph.D. synthetic chemist.

Thursday, March 17, 2016

Job posting: scientists, nanoComposix, San Diego, CA

From the inbox, a couple chemist positions in San Diego, CA. The first, a research associate position at nanoComposix:

DESIRED SKILLS
  • Experience fabricating, functionalizing, and processing nanomaterials
  • Experience with the bioconjugation of targeting molecules to surfaces or particles
  • Experience with optical microscopes, UV-Vis, DLS, Zeta-Potential,TEM, or SEM

DESIRED SKILLS
  • Sol-gel chemistry, specifically the fabrication and functionalization of silica and titanium dioxide nanoparticles and core-shell composites. 
  • Synthesis of unagglomerated, low coefficient of variation gold, silver, copper, platinum, and magnetite nanoparticles. 
  • Strong analytical background including experience with TEM, DLS, Zeta Potential, and optical microscopy and spectroscopy.
  • Nanoparticle surface functionalization for transfer between organic and aqueous dispersions. 
  • Pilot or production scale chemistry including reactor design, production scale manufacturing, or continuous flow processes.
  • Experience with the bioconjugation of targeting molecules to surfaces or particle, 
Best wishes to those interested. 

Wednesday, March 16, 2016

San Diego Career Fair numbers

Reported to the ACS Council this morning at the San Diego National Meeting:
Job Seekers: 739
Employers: 30
Positions: 106
Recruiters Row Booths: 13 
Resume reviews: 360
Mock interviews: 217
The 7:1 ratio is a little higher than normal, but not too high (I should really track this better.)

(There was no white board this year.) 

You forget how blue the skies are in San Diego

Horton Plaza skyine (Credit: Chemjobber)
March in San Diego is lovely.