Monday, May 27, 2024

Memorial Day; back tomorrow

Sacramento Valley National Cemetery
Credit: Tech. Sgt. Daniel Peterson, 349th Air Mobility Wing 

Today is Memorial Day in the United States; it's a national holiday.

Back tomorrow.

Friday, May 24, 2024

Have a great weekend

Well, this has been a restful week, so I'm not going to complain. I hope that you had a great week, and that you have a great weekend. See you on Tuesday. 

Thursday, May 23, 2024

Job posting: Postdoctoral Research Fellows - Air Force Science & Technology Fellowship

Via C&EN Jobs: 

The National Academies of Sciences, Engineering, and Medicine administers postdoctoral and senior fellowship awards at the U.S. Air Force Research Laboratory (AFRL), the U.S. Air Force Institute of Technology (AFIT), and the U.S. Air Force Academy (USAFA) under the Air Force Science & Technology Fellowship Program (AF STFP).

We are seeking highly qualified candidates who are U.S. citizens and hold, or anticipate earning, a doctorate in a variety of fields of science or engineering.

Application deadline dates (four annual review cycles):

  • February 1
  • May 1
  • August 1
  • November 1

Awardees have the opportunity to:

  • Conduct independent research in an area compatible with the interests of the Air Force laboratories
  • Devote full-time effort to research and publication
  • Access the excellent and often unique Air Force research facilities
  • Collaborate with leading scientists and engineers

Awardee benefits include:

  • Base stipend starting at $76,542; may be higher based on experience
  • Health insurance (including dental and vision), relocation benefits, and a professional travel allowance

For detailed program information, to search for AFRL, AFIT, and USAFA Research Opportunities, and to contact prospective Research Adviser(s), visit www.nas.edu/afstfp

Full ad here. Best wishes to those interested. 

Wednesday, May 22, 2024

France has scratch-and-sniff stamps?

Via the New York Times

Joining the ranks of the screen goddess Brigitte Bardot and the Eiffel Tower, another French treasure is being celebrated with its own postage stamp: the baguette.

And this one is scratch-and-sniff.

The latest showcasing of French cultural heritage as Paris prepares to host millions of visitors for the Summer Olympics and Paralympics, the new stamp features a cartoon image of a baguette wrapped in a tricolor ribbon.

It was unveiled by France’s postal service on Thursday — May 16, the feast day of Saint HonorĂ©, the patron saint of bakers.

“The baguette, the bread of our daily lives, the symbol of our gastronomy, the jewel of our culture,” the usually not-flashy postal service raved in its description of its new offering...

...Thanks to scratch-and-sniff technology, it will also transport “bakery fragrances” to those lucky enough to receive a letter from France.

I suppose that it doesn't surprise me that there are scratch-and-sniff stamps, but I guess I would be curious as to which European flavorings company was given the contract to develop "baguette smell." 

(From the essential "Nose Dive" by Harold McGee, 'white bread crust' has the components of acetyl pyrroline, methylbutanals, methylbutyric acid, methional, diacetyl, furaneol, furfural and pyrazines.) 

Tuesday, May 21, 2024

The 2024 Chemistry Faculty Jobs List: 556 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 556 research/teaching positions and 86 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On May 30, 2023, the 2023 Chemistry Faculty Jobs List had 628 research/teaching positions and 83 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Monday, May 20, 2024

Job posting: Principal Scientist/Senior Principal Scientist, Discovery Chemistry, Gilgamesh Pharmaceuticals, remote

From the inbox: 

We are seeking a dynamic and experienced professional to join our team as a Principal Scientist, Discovery Chemistry. The successful candidate will play a pivotal role in driving the design, selection, and advancement of small molecule drug candidates across a variety of CNS targets. 

This position requires broad-based expertise across chemical synthesis, molecular design, pharmacology, and ADME, and an ability to integrate this diverse expertise to both deliver on individual goals and interface with and assist other members of the company’s small and dynamic team. Specific responsibilities will include management of external chemistry FTEs, compound and synthetic route design, management of compound inventory and logistics, advancement of compounds through a screening funnel to identify development candidates, analysis of biological and ADME data to guide iterative design, and preparation of patent applications. The position will report directly to the CSO/Head of Chemistry and will work closely with multiple colleagues in the discovery team, across chemistry, biology, and ADME functions.

Remote role, ideally in the NY/NJ area. Full ad here. 

Interested? Email mike@gilgameshpharmaceutical.com

Best wishes to those interested. 

C&EN: "Ginkgo to cut costs as pandemic-related business slows"

Via this week's C&EN (article by Matt Blois): 

Ginkgo Bioworks is cutting costs and laying off staff after losing $166 million in the first quarter. Revenue from its disease-monitoring business surged during the COVID-19 pandemic but was down more than 50% compared with the first quarter of 2023. Its business that engineers microbes for biomanufacturing customers slowed because fewer start-ups were seeking help. Ginkgo plans to cut spending on laboratory space by 60% and labor by 25% over the next year...

That stinks for Gingko workers. Best wishes to them. 



Friday, May 17, 2024

Have a great weekend

Well, this has been a better week than I thought. Getting things done, but not quite at the rate I hoped. Here's hoping for a great weekend for you, and we'll see you on Monday. 

House Oversight and Accountability Committee advances BIOSECURE Act

Via Politico:

A group of China-based biotech companies faced a setback on Wednesday as the House Oversight and Accountability Committee overwhelmingly advanced legislation that has them in the crosshairs, Megan reports.

The bill, called the BIOSECURE Act, would effectively ban the operations of Chinese “companies of concern” in the U.S. by prohibiting them — and any businesses that use their products — from receiving federal contracts, grants or loans.

One of those companies, WuXi AppTec, is used by many large drugmakers to help develop and bring medicines to market. In the leadup to the markup, WuXi AppTec and WuXi Biologics, which have China-based parent companies, had been urging lawmakers on the House panel to remove them from the bill.

The companies have been pushing back on lawmakers’ accusations that they have ties to the Chinese government and pose a national security risk. WuXi AppTec flew executives, including Richard Connell, the company’s U.S. and EU president, to Washington as part of the push. Elizabeth Steele, one of WuXi Biologics’ lobbyists, said the company has been working to “educate legislators on what our company does and doesn’t do.”

Last month, a spokesperson for Complete Genomics, a California-based company owned by MGI Tech, said its inclusion in the bill “is based on misunderstandings and representations about the company.”

The BIOSECURE Act has continued to gain momentum since a Senate committee approved its version in March.

It will be fascinating to see what happens with this. I predict passage in the House, and either passage in the Senate, or a quiet death there. 

Sodium hydroxide tanker explodes in Ohio

Credit: Akron Beacon Journal/News 5 Cleveland
Via the Akron Beacon Journal, this news: 

A tanker carrying sodium hydroxide exploded at the Royal Chemical plant Wednesday morning in Macedonia resulting in three reported injuries, according to Macedonia Fire Chief Brian Ripley.

Two of the three people injured were transported to Metro General Hospital in Cleveland, one of them with life-threatening burns and the other with non-life-threatening, but critical burns, Ripley said.

The third individual was evaluated on the scene.

Investigators are still unsure what caused the explosion, which Ripley said occurred around 11:40 a.m. He said when crews arrived, the tanker had been split in two due to the explosion with half of the tanker inside of the building and the other half outside of the building...

I'm genuinely surprised this happened, i.e. how does sodium hydroxide cause anything to explode? I predict two things - either the tanker was over-pressured (i.e. the loader decided to pump it in without a vent) and ruptured, or the tanker had water in it and sodium hydroxide fluid was pumped in and it got hot, boiled and then ruptured. Kind of strange. 

Thursday, May 16, 2024

Job posting: Senior Scientist, Chemical Synthesis, AstraZeneca, Waltham, MA

Via BlueSky: 

We are seeking for a highly motivated organic chemist who is passionate about organic synthesis to join AstraZeneca in our Waltham, MA location. This is laboratory-based position within world-leading global Oncology Chemistry group with a strong record of delivery and innovation. We are dedicated to fostering a diverse and inclusive work environment, and we welcome individuals from all backgrounds to apply.

You will be responsible for conceiving and implementing innovative synthetic strategies within projects, use your personal lab delivery expertise to help solve complex synthetic chemistry problems to deliver the next generation of oncology medicines. This includes traditional small molecules, and new targeting modalities to treat cancer. You will have the opportunity to get involved in multi-disciplinary teams and contribute to oncology pipeline progression. You will use your extensive knowledge of organic synthesis, in combination with high throughput experimentation and automation, to discover innovative approaches to synthetically challenging molecules, and to develop robust chemistry amenable to scale-up.

Essential Qualifications:

  • PhD in organic chemistry and 0-5 years of relevant industrial experience OR BS/MS and 5+ years of relevant industrial experience
  • Expert knowledge of modern methods of synthetic organic chemistry including late-stage functionalization
  • Passion for organic synthesis with demonstrated expertise in multi-step synthesis, new synthetic routes design and optimization
Full ad here. Best wishes to those interested. 

Wednesday, May 15, 2024

Congress pushes out BIOSECURE Act deadlines to 2032, WuXi denies transfer of IP

Via Reuters (May 10), this update to the BIOSECURE Act: 

A new version of a congressional bill that would restrict U.S. business with certain Chinese biotechnology companies including WuXi AppTec and BGI would give U.S. companies until 2032 to end work with the firms, extending the amount of time to find new partners.

The latest Biosecure Act also adds WuXi Biologics, opens new tab to a list of biotech companies of concern, according to a copy seen by Reuters. The other companies on the list are BGI, MGI, Complete Genomics and WuXi AppTec. 

The companies are largely contractors that do research and manufacturing work for pharmaceutical and biotech firms around the world.

The revised bill was introduced on Friday. A U.S. House of Representatives committee is expected to decide next week whether to move it forward, according to a House Committee on Oversight and Accountability spokesperson.

The committee markup, expected Wednesday, is a procedural step where they discuss and vote on the text of the bill. A similar Senate bill was approved by a committee there in March.

I'm not surprised this happened, i.e. Congress isn't that stupid and doesn't want to be on the hook for cutting off American medicine supplies. But I am, overall, pretty surprised that this is actually seeming to march its way through Congress and onto the President's desk. We'll have to see what comes out of markup today, I suppose. 

In other news, WuXi denies that it gave information to the Chinese government (article by FiercePharma)

Of all the allegations thrown at WuXi AppTec during an ongoing U.S. biosecurity crackdown, a recent intelligence report that the company had transferred an American client’s intellectual property to Beijing without consent was one of the most damning. Facing potential sanctions, the contract research and manufacturing giant is now rebutting the claim in a new letter to the U.S. Department of Defense (DOD).

WuXi Apptec’s leadership is “not aware of, would never approve, does not condone, and has a zero-tolerance policy against any attempt to mishandle or transfer a customer’s intellectual property (IP) to any unauthorized party,” the company said in a recent letter penned by co-CEO Steve Yang and its U.S. and European president Richard Connell, Ph.D.

The WuXi executives addressed the May 3 letter to the DOD’s assistant secretary of defense for industrial base policy, Laura D. Taylor-Kale, Ph.D.

It's somewhat less than Shermanesque*, but a denial is not a studied silence either. 

This is all very fascinating, and it remains (although not much remains!) to be seen whether the BIOSECURE Act will gain Congressional approval and a presidential signature. 

*"did not and would never hand over customer intellectual property to the government of China" would be my proposal if I were the one to write it

(An obvious, though impertinent question - why hasn't WuXi simply donated several million dollars to the Trump 2024 campaign, and simply purchased their support much like a TikTok investor attempted to do? If this is really happening and it would obviously have a very large impact on future business, time to give it a shot? Time for WuXi to buy a ticket to Miami?) 

Tuesday, May 14, 2024

The 2024 Chemistry Faculty Jobs List: 556 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 556 research/teaching positions and 86 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On May 23, 2023, the 2023 Chemistry Faculty Jobs List had 627 research/teaching positions and 82 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Monday, May 13, 2024

Paraffin as rocket fuel?

Via Bloomberg, this news: 

Companies are trying all kinds of things to find their way in the increasingly competitive space industry.

A German startup is adding candle wax to that list.

HyImpulse Technologies last week launched a sounding rocket powered by a combination of liquid oxygen and solid paraffin – a petroleum byproduct that’s a key ingredient in candles.

Mario Kobald, who co-founded the company in 2018, is taking this approach because he saw too many young companies trying to develop rockets similar to Elon Musk’s industry giant SpaceX, which uses liquid oxygen and kerosene to fuel its workhorse Falcon 9 rockets.

“You cannot compete with the costs of a system that’s already on the market for many years when you have established players like SpaceX,” says Kobald, who started HyImpulse with several former classmates from the University of Stuttgart, where he received a PhD in aerospace engineering.

Gotta say, the relative price and safety of paraffin is probably quite attractive... 

Friday, May 10, 2024

Have a great weekend

So this was a great week, all things considered. Sometimes you feel like you phoned it in, but I guess things turned out all right, and that will have to do. It helps to have a great team around you, and I felt like this week was great for learning about that as well. I hope that you had a great week, that you have a wonderful weekend and that we'll see you on Monday. 

Wednesday, May 8, 2024

Beethoven had lead poisoning from drinking wine

Via the New York Times, this science news: 

...Kevin Brown, an Australian businessman with a passion for Beethoven, owned three of the locks and wanted to honor Beethoven’s request in 1802 that when he died doctors might attempt to figure out why he had been so ill. Mr. Brown sent two locks to a specialized lab at the Mayo Clinic that has the equipment and expertise to test for heavy metals.

The result, said Paul Jannetto, the lab director, was stunning. One of Beethoven’s locks had 258 micrograms of lead per gram of hair and the other had 380 micrograms.

A normal level in hair is less than 4 micrograms of lead per gram.

“It definitely shows Beethoven was exposed to high concentrations of lead,” Dr. Jannetto said.

“These are the highest values in hair I’ve ever seen,” he added. “We get samples from around the world and these values are an order of magnitude higher.”

Beethoven’s hair also had arsenic levels 13 times what is normal and mercury levels that were 4 times the normal amount. But the high amounts of lead, in particular, could have caused many of his ailments, Dr. Jannetto said.

The technique used (unsurprisingly) was ICP-MS. (Here's the scientific letter.) It's a shame that a brilliant mind was also poisoned... 

Tuesday, May 7, 2024

The 2024 Chemistry Faculty Jobs List: 555 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 555 research/teaching positions and 86 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On May 16, 2023, the 2023 Chemistry Faculty Jobs List had 626 research/teaching positions and 82 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Job posting: Formulation Chemist, ACTEGA North America Technologies, Providence, RI

Via C&EN Jobs, this positions in Providence, RI:  

General Summary:

The Formulation Chemist spearheads the development new products through innovative solutions, while also identifying emerging technologies pertinent to business objectives. Collaboratively build systems and support product/engineering teams and offering expertise in energy cure chemistries to build robust systems. Develop and commercialize new products; Provide scale-up support and technical guidance to production. As well as ongoing project assignments, formal project reports writing, and research & development activities, as needed. 

Essential Job Functions & Responsibilities:

  • Develop Adhesives formulations, preferably UV curable, aimed at achieving best performance specific to well-defined end use requirements.
  • Independently design experiments, execute testing, collect data, and draw conclusions from development work.
  • Develop and support on projects from concept to commercialization.
  • Hands on working in the laboratory environment and support with printing of various UV-curing chemistries on press to test new formulation designs....

Qualifications & Requirements:

  • BS degree with 7 years of experience, or MS with 5 years of experience, or PhD with 3 years of experience in Chemistry, Chemical Engineering, Material Science or Polymer Chemistry. Experienced, hands-on scientist with strong laboratory technique and problem-solving skills, including proficiency in designing experiments.
  • Background in formulation and chemistry, specifically with UV-curable and/or water-based inks, coatings, and preferably adhesives.
  • Strong chemistry background in polymer structure property relationships in formulations. Understanding of chemical regulatory regulation for USA, Europe, and United Kingdom for printing inks. Knowledge of the Graphic Arts Printing Industry: flexographic, gravure, screen and offset printing applications. Understanding of various object printing on substrates such as Glass, Aluminum, and plastics is a plus. Ability to work in a small group setting.

Posted salary is "From $90,000 per year + 10% annual bonus target." Full ad here. Best wishes to those interested.

Monday, May 6, 2024

C&EN: Survey indicates the most desired skills for entry-level chemistry from industrial chemists

Also in this week's C&EN, this very interesting news about a survey (and J. Chem. Ed. paper by Hamilton, Castillo and Atkinson) (article by Krystal Vasquez): 

...To answer this question, Hamilton and his colleagues surveyed chemists from 80 chemical-related companies. The researchers found that professionals want chemists with bachelor’s degrees to have some expertise in mass spectrometry, liquid chromatography, gas chromatography, ultraviolet-visible spectroscopy, and infrared spectroscopy (J. Chem. Educ. 2024, DOI: 10.1021/acs.jchemed.3c00990).

They also value chemists that have good communication, collaboration, problem-solving, and critical thinking skills.

The researchers then compared their survey results to existing literature about instrumentation and other skills being taught in undergraduate courses. Hamilton says that most undergrad lab courses do “a decent job” of giving students access to most of these top-five instruments. “But I think we could definitely be doing a better job.”

It's not surprising that LC and GC are up there, but I'm a bit surprised that mass spec is up there as well. What is weirder to me is that basic maintenance was not a skill set (sub skill set?) that was not called out in the article and/or the survey results. Nevertheless, it sounds like there wasn't a lot of data out there about this, so this is really great that the authors put together this survey. 

(...why doesn't ACS do this?...) 

C&EN: "WuXi AppTec revenues slump in the first quarter"

In this week's Chemical and Engineering News, this news (article by Aayushi Pratap): 

Shanghai-based WuXi AppTec, which is a subject of a proposed US bill that aims to cut business ties with a handful of Chinese pharmaceutical service companies, announced first-quarter sales of $1.1 billion, down 11% from the prior year. Revenues excluding those from COVID-19 commercial projects dropped 1.8%. The company expects to generate sales of over $5 billion this year despite what it calls “uncertainties in the external environment,” a possible reference to the proposed US legislation.

This is interesting, in that I don't think this Q1 slump is about the BIOSECURE Act. Rather, I wonder if it is connected with a potential slowdown in global demand for pharma services? It's hard to know. This is worth following, I think...

Friday, May 3, 2024

Have a good weekend

Well, the thing that needed to get done finally got done. Maybe I'll escape with my hide intact. I am looking forward to a fun weekend. I hope that you have a great weekend, and see you on Monday.

The impacts of the new EPA rule on methylene chloride to laboratories in the United States

I have been making nervous noises about the EPA ban on methylene chloride, and I believe that my thoughts are confirmed (unbeknownst to me) by the American Chemical Society's comment on the (then proposed) rule (opens PDF, via ACS' Will Hartwig):

ACS appreciates the current proposed rule’s goal of protecting public health. However, ACS is concerned that the current proposal to regulate methylene chloride, also known as dichloromethane (DCM), fails to account for its use in small scale and particularly academic teaching and research laboratories.

Both the EPA (with 40 CFR 262 Subpart K) and OSHA (with 29 CFR 1910.1450) have recognized that regulations aimed at protecting workers in industry do not translate to academic laboratories. As currently structured, the rule would be extremely challenging for academic institutions to implement and would negatively impact research and teaching. The proposed rule is not appropriate for academic laboratories because exposures are low, infrequent, and well managed using existing regulations and engineering controls (e.g. chemical fume hoods)

From my analysis of the new rule, any workplace that uses methylene chloride must:

  1. determine and document who uses DCM
  2. document and monitor the exposure during usage, which
  3. means getting a monitoring device (likely a PID, is my guess, which is a $4000 instrument)*
  4. determining and documenting TWAs for each usage and user

(I've read enough comments from industry to understand that the PIDs that are available aren't particularly well suited for this usage, so that's another problem. (page 6, PDF)

I'm not a chemical safety professional, so I could be wrong. But that's my basic read of the new rule, and I think it is matched by the ACS. No professor is going to this - instead, they're going to either 1) ignore the new rule or 2) ban the use of DCM in their labs. Hard to know which one they will choose.

I'd love people's opinions.


Thursday, May 2, 2024

Job posting: Principal Scientist, Medicinal Chemistry, San Diego, CA

Via friend of the blog Alex Goldberg, this job posting: 

Principal Scientist, Medicinal Chemistry

The successful candidate will lead lab chemistry efforts in the department enabling projects across the portfolio. They will also utilize the Genesis Therapeutics platform and assist medicinal chemistry efforts in drug discovery programs from Hit ID through candidate nomination. They will collaborate on multidisciplinary drug discovery projects, direct CRO chemists, and be responsible for synthetic chemistry strategy. The candidate will be expected to be a synthetic chemistry leader to drive programs.

Job Responsibilities:

  • Formulate and implement synthetic chemistry strategies across a portfolio to drive drug discovery programs from Hit ID through candidate nomination.
  • Identify opportunities to improve lab functions through technology, synthetic chemistry, or external resources.
  • Utilize the Genesis platform to execute drug discovery programs.
  • Use SBDD principles, optimize physiochemical properties, interpret in vitro and in vivo ADME/PK/Toxicology data, and understand in vitro and in vivo biology data to drive programs.
  • Work with other drug discovery disciplines (biology, DMPK, software engineers, computational chemists) to drive hypothesis driven decisions, improve the platform and contribute to the scientific excellence of the company.
  • Communicate and engage regularly with project team members.
  • Interact and direct a team of CRO chemists anywhere in size from 5-20.
  • Mentor internal chemists as well as other scientific disciplines on synthetic chemistry strategy.

Education and Experience Requirements:

  • PhD in synthetic organic chemistry or medicinal chemistry with at least 6 years of industrial drug discovery experience OR
  • MS in synthetic organic chemistry with at least 10 years of industrial drug discovery experience
Full ad here. Best wishes to those interested. 

Wednesday, May 1, 2024

EPA bans most uses of methylene chloride

Via C&EN, this news: 
The US Environmental Protection Agency has banned most uses of methylene chloride, a solvent that has been linked to a number of adverse health effects and some deaths.

Since 1980, at least 88 people have died from acute exposure to methylene chloride, the agency says. Longer-term exposure can also lead to liver damage and the development of at least six different types of cancers, it adds.

Methylene chloride is the second compound, after asbestos, to be banned under the revised Toxic Substances Control Act. The ban, which follows a risk assessment and an April 2023 proposal, will phase out all consumer uses within a year and most industrial and commercial uses within the next 2 years.

Uses of methylene chloride that are exempt from the ban include as a raw material for producing electric-vehicle batteries and climate-friendly refrigerant chemicals. And methylene chloride can continue to be used as a laboratory chemical.

“For each use of the chemical that will continue, EPA has developed a first-of-its-kind worker protection program, so that the workers who are helping make and use the chemical . . . are protected, as they deserve to be,” Michal Freedhoff, assistant administrator for the EPA’s Office of Chemical Safety and Pollution Prevention, said during a press briefing. Workplaces that are exempt from the ban will have 18 months to put worker protections in place.

Pharmaceutical use isn't covered by TSCA. Here's the finalized rule. I have strong suspicions that the workplace safety requirements are pretty strict, but I'm going to withhold judgment until I read the whole thing, which I haven't.  

Tuesday, April 30, 2024

The 2024 Chemistry Faculty Jobs List: 554 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 554 research/teaching positions and 86 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On May 9, 2023, the 2023 Chemistry Faculty Jobs List had 626 research/teaching positions and 82 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Job posting: professor of practice, Department of Chemistry, Tulane University, New Orleans, LA

From the inbox: 

The Department of Chemistry at Tulane University invites applications for a Professor of Practice position beginning in the Fall 2024. The successful applicant will have a Ph.D. in Chemistry with expertise in Organic Chemistry. Duties will include supervising General Chemistry Laboratories, which, in total, involves about 17 teaching assistants, and teaching a section of General Chemistry lecture class (~150 students).  The Department of Chemistry recognizes and rewards innovative and quality teaching. Candidates interested in creating and adopting pedagogical innovations will find many opportunities and support to pursue their interests. The successful candidate will have a record of excellent teaching and mentoring at the undergraduate level, and commitment to student-centered teaching and to increasing diversity in chemistry.  

The Professor of Practice appointment is renewable every three years (initially) and every five years after promotion to Senior Professor of Practice. 

Search started on April 22. Full ad here. Best wishes to those interested. 

Monday, April 29, 2024

If a lab accident happened and no one saw it, did it really happen?

In this week's C&EN, this letter to the editor: 

I just had to comment on the two pieces from Newscripts in the April 1 issue of C&EN (page 40). In the first piece, the revelation by Jessica Pomerantz reminded me of an experience I had in 1977 in a senior-level physical chemistry class at Iowa State University. 

It involved a Lewis acid-base reaction of boron trifluoride and trimethylamine in a rather complex glass network that included a liquid-nitrogen cold trap because the reaction was so exothermic. The instructions for valve settings and operation were quite specific and stated that if they were not followed explicitly, the apparatus could explode. I arranged all valves meticulously, or so I thought, and then opened the valve on the BF3 cylinder, which was connected to the glassware inlet by a rubber hose. Unfortunately, the one valve I forgot to open was the inlet valve to the apparatus. Within seconds, the hose popped off, and I had a fuming ball of BF3 within 1 ft (0.3 m) or so of my face. I had the presence of mind to shut off the cylinder valve, and then I watched as the fuming cloud, which stayed intact, floated to the ceiling and rolled all the way to the other corner and escaped through a roof vent. It reminded me of the movie The Blob, except this blob rolled along the ceiling and not the floor. My classmates and the teaching assistant were so absorbed in their own work that they did not observe the blob. Nobody at Iowa State ever learned of my slight mistake. I successfully completed the experiment on the second attempt.

This brings me to the second Newscripts article. During my many years in industry and to this day, I have written numerous articles for various technical trade magazines, including Chemical Engineering, Power Engineering, and others. I am now a self-employed technical writer and consultant. From the experience above and several others during my career (such as tripping and falling into several inches of yucky flue gas desulfurization sludge), I can decidedly appreciate the title of the second piece, “And This Is Why We’re Journalists Now.”

Brad Buecker
Lawrence, Kansas

I've had my share of near misses and dumb errors and I'm glad that I can look at them with humor now. 

It is strange to me how laboratory chemical experiments of the past were seemingly so complex compared to the microscale experiments I performed in my undergraduate education in the 1990s. While we certainly generated less waste, I wonder if some of the really cool chemistry was lost to time...

(The answer to the headline is, of course, "yes.")

C&EN: "Dow and BASF post upbeat first-quarter results"

In this week's Chemical and Engineering News, this good news (article by Alex Tullo): 

First-quarter financial results are out from Dow and BASF. And if these two chemical giants are setting the trend for their peers—which are due to report their results over the next several weeks—the industry may be turning the corner after a dismal 2023.

Dow’s sales fell 9.2% from the year-earlier period, while adjusted earnings slipped 5.1%. Sales and prices were down across all its business.

But compared with the fourth quarter of 2023, Dow’s sales and earnings were up 1.4% and 28.8%, respectively. A small decline in its core packaging and specialty plastics segment was more than offset by growth in its industrial intermediates and infrastructure business and its performance materials and coatings unit.

Excess capacity hit the petrochemical industry hard last year, particularly in high-cost regions such as Europe. But Dow CEO Jim Fitterling was upbeat during his April 25 conference call with analysts. “Most of the capacity is in the market already, and we’re seeing volume growth,” he said.

Dow’s own operating rates rose 10% in the first quarter, Fitterling reported. And he said lower-cost locales like the US and the Middle East should perform strongly. “We have been through the worst of it on the slowdown in the cycle,” he added.

BASF announced that it “got off to a solid start in 2024.” Its sales fell 12.2% and its earnings dropped 12.9% from the year-earlier quarter. The company attributes the decline primarily to lower prices. A few key businesses, such as chemicals, materials, nutrition, and personal care, saw improvements in volumes.

I used to think that basic chemical manufacturers' businesses were pro-cyclical (i.e. they do well when the broader economy does well), but the post-pandemic economy feels like that has broken that connection. Here's hoping that this good news means good news for the broader economy as well. 

Friday, April 26, 2024

Have a good weekend

Well, this hasn't been the best week, to be honest. Here's hoping we get things done that need to get done. I hope you have a great weekend. See you on Monday. 

Novartis shifting manufacturing due to threat of BIOSECURE Act

Via FiercePharma, this news: 

As the BIOSECURE Act threatens to upend relationships with Chinese contractors and western biopharma companies operating in the U.S., Novartis has elected not to adopt a “wait and see” attitude.

Novartis, like many drugmakers, has ties to Chinese firms in the manufacturing and contract research space, the Swiss pharma’s CFO, Harry Kirsch, said on a press call Tuesday during its first quarter financial results. Amid the threat of a looming biosecurity crackdown by the U.S. government against many of those Chinese biotechs, Novartis is now “actively” managing the situation, Kirsch said.

“So, by the time this comes into effect, we will have no exposure from our planning,” the CFO explained, adding that the situation will be “mitigated in a very reasonable timeframe.”

Kirsch went on to explain that the company is weighing changes to its contracting relationships with Chinese companies “so that we are fully aligned” with potential U.S. regulations.

Novartis’ decision to cut ties with certain Chinese contractors follows the House Select Committee on the Strategic Competition between the United States and the Chinese Communist Party’s unveiling of the BIOSECURE Act in January.

The bill, which is still subject to further review and modification before it potentially becomes law, aims to keep U.S. taxpayer dollars out of the hands of “foreign adversary biotech companies” that allegedly pose a national security concern.

I'm surprised to hear this, but I guess this indicates that large pharma companies seem to think that the BIOSECURE Act has a solid chance of passing. I'm genuinely skeptical, but we will see. 

Thursday, April 25, 2024

Job posting: scientist, discovery chemistry, Merck

Via Twitter, this tweet from Dani Schultz: 

We have multiple openings in Boston, San Francisco and West Point (PA) spanning Bachelor's, Master’s, entry level PhD and PhD with experience. Go to http://jobs.merck.com and search for ‘Discovery Chemistry’ or ‘Peptide’! 

Here's one of the ads for the West Point site: 

Our company is currently seeking passionate synthetic organic or medicinal chemists for positions within the Discovery Chemistry Department located at our West Point, PA site. The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying innovative synthetic chemistry, analytical techniques, and data analysis to design and synthesize drug candidates and intermediates.

Successful candidates must have excellent interpersonal, collaboration, and communication skills in a team environment and a proven record of solving complex problems. Additionally, it is expected that the successful candidate will learn quickly through on-the-job training to become increasingly skilled and independent in reaction setup, route design and optimization.

Specific responsibilities will include:

  • Collaborative and independent synthetic route design, execution, and optimization to access assigned target molecules using modern synthetic chemistry techniques
  • Selection and application of appropriate purification techniques including flash chromatography, high performance liquid chromatography (HPLC) and recrystallization
  • Acquisition and interpretation of analytical data such as NMR and LC/MS

Full ad here. Best wishes to those interested.

Wednesday, April 24, 2024

You can get drunk without drinking alcohol?

Via the New York Times, I learned about auto-brewery syndrome: 

...In Belgium, the brewery worker — a 40-year-old man who wishes to remain anonymous, according to his lawyer — was pulled over by the police in April 2022 and registered a blood-alcohol reading that was more than four times the legal limit. A month later, he was pulled over again and registered more than three times the limit.

It was the third time the man had been cited — he had been pulled over and fined for driving under the influence in 2019. He was unaware that he had A.B.S. until his latest charge — tests administered by three doctors confirmed that he had the condition and validated his claim in court.

“I think he was somehow relieved that he finally knew what was up,” the man’s lawyer, Anse Ghesquiere, said. Her client is now following a strict diet and receiving medical treatment to avoid flare-ups and manage the condition...

According to this paper, it's cured with anti-fungal medication and a low-sugar diet. To be honest, this doesn't sound very fun. 

Tuesday, April 23, 2024

The 2024 Chemistry Faculty Jobs List: 552 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 552 research/teaching positions and 86 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 25, 2023, the 2023 Chemistry Faculty Jobs List had 622 research/teaching positions and 81 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Monday, April 22, 2024

C&EN: Disagreement about the decision to vent and burn the vinyl chloride

In this week's issue of Chemical and Engineering News, this comment: 

Thanks for publishing Priyanka Runwal’s fine article on East Palestine, Ohio, in the Feb. 26, 2024, issue of C&EN (page 24).

The Norfolk Southern train derailment should have received a prompt federal response since the onboard cargo was being used in interstate commerce (from Madison, Illinois, to Conway, Pennsylvania). The State of Ohio did respond to this disaster, but it took some poking and prodding for the state to act.

I spoke to the governor’s representative in my region, who indicated that the state maintains multiple boards and commissions. The State Emergency Response Commission looked like a good choice for active engagement. But membership was limited to elected officials, emergency management personnel, environmental advocates, firefighters, first responders, industry and trade personnel, law enforcement personnel, and utility personnel. Nothing to engage scientists and engineers in this emergency.

The lack of an expert in science and engineering in charge rendered communication of the facts to residents of East Palestine, people in the nearby communities, and those who sought answers to be spotty at best.

It is my considered opinion that the decision to vent and burn the vinyl chloride was made without expert consultation. As Runwal’s piece noted, former American Chemical Society president William Carroll pointed out in a hearing that the polymerization reaction of vinyl chloride to polyvinyl chloride requires an initiator. Free radicals, such as chemicals containing peroxides, can initiate polymerization. I don’t know whether the conditions existed for the polymerization of vinyl chloride to have occurred.

People in the East Palestine region are still suffering from the response to the derailment. The federal government response to East Palestine must not be the norm, and the states should expand the relevant boards and commissions to include scientists and engineers. In events such as East Palestine, the designated scientists and engineers would handle communicating the facts to those in the impacted communities and beyond.

ACS should play a central role in having regional experts available to the state and federal entities needing such guidance. This is a role in which ACS can make a real, quantifiable difference.

Mitigating disasters is important, as are the lives of the people in the impacted areas. While each incident is different, there is nothing more reassuring to the people in the impacted areas than knowing that they have the best available facts (in real time) and that we’ve got their backs.

David M. Manuta, Waverly, Ohio

I'm terribly curious to see what the various agencies report when the ultimately do so... 

Friday, April 19, 2024

Have a great weekend

Well, I was gifted two quiet days this week, and I got half of what I wanted to get done, done. So here's hoping I can get the other half done on Friday. I hope that you got accomplished what you hoped to, and that you have a fantastic weekend. I know I will try to! See you on Monday. 

Would you pay $1500 to be an Japanese steel manufacturing worker?

Via the New York Times, this very fun trip to an ancient Japanese steel foundry: 

...Safety was paramount because around the flames, at various stations, milled a team of some 20 excited tourists, a mix of both Japanese and a few foreigners, all dressed in very hip dark gray jumpsuits. These were people paying roughly ¥200,000, or about $1,500, for the chance to be a worker in a tatara-ba for a day and night. (They would get to keep the jumpsuits and a small piece of raw steel as souvenirs.) Their faces and hands were streaked by charcoal.

Jewel steel is produced by sprinkling iron sand — alluvial (river-deposited) sand saturated with iron — slowly over a charcoal pit. The tourists spent hours chopping the pine charcoal to precise sizes. They used scoops woven from bamboo to gather heaps of charcoal and dump them atop the furnace.

Off to the side stood a man named Noriaki Yasuda. He was the designated conductor — called a murage — of this slow dance between heat, charcoal and dampened iron sand. Dressed in an electric blue jumpsuit, he stood out in beautiful, almost poetic, contrast to the licking orange flames.

Monitoring the airflow, the color of the fire and the height of the charcoal with paternal concern, Mr. Yasuda scowled and watched, sometimes retreating to sit in his dark alcove, his arms crossed, still scowling and watching. To produce steel using the tatara technique, it turns out, you spend a lot of time watching.

I'm delighted (and not surprised) that there is a touch of chemistry: 

...“Steel is just iron with a little bit of carbon,” Mr. Yasuda explained to me. When I finally built up the courage to talk with him, his face lit up in a wide smile from behind his mask. (Everyone was wearing masks, less out of Covid concerns and more because of the charcoal dust.) He casually led me to a blackboard in the back of his resting space and sketched out the basic chemical formulas of what was happening in the furnace, how charcoal serves two purposes. First, it burns much hotter than wood. And second, its carbon atoms are essential to the formation of steel; embedded between iron atoms, they increase the strength of the metal.

First, as someone who works in chemical manufacturing, I'm guessing that we cannot get tourists to pay $1500 to work a shift - more's the pity. It is also interesting how they are careful with the size of the charcoal - makes sense, i.e. more uniform pieces allow for better control of the heat. Fun article - read the whole thing. 

Thursday, April 18, 2024

Job posting: chemistry teacher, Regis High School, New York City, NY

Via C&EN Jobs: 

Position Summary

Regis seeks a qualified candidate to join its faculty as a Chemistry Teacher beginning September 2024 for the Academic Year 2024-2025. This is a full-time faculty position. Position comes with full benefits. Work hours may vary and will include some evenings and weekends for special school events. Salary is very competitive for the New York City area and is commensurate with experience. The 2024-2025 school year for faculty members ends on June 13, 2025.

Job Responsibilities

  • Supports and Advances the Catholic Jesuit Mission of the School
  • Works in collaboration with the administration in observing the principles and ideals for which Regis High School stands for
  • Devotes energies to teaching in conformity with the policies of Regis High School and is subject at all times to the general control and supervision of the Principal
  • Will perform services that include the preparation of examinations, the correction and assignment of grades, and assigned proctoring
  • Responsible for ongoing professional development, the customary conferences with students and parents, individual guidance of students, serving as an academic advisor with a student advisement group, direction of student extracurricular activities, service on faculty committees, active service in studying department and school issues, preparation of syllabi, attendance at events listed in the school’s Faculty Handbook under “Faculty Staff Participation in Key Events,” attendance at faculty meetings, and participation in other such professional incidental services, in the judgment of the Principal, the needs of the school require
  • Will be generally available to the students in their assigned department resource room through the school day when not teaching class; further, is to have one hour after school availability weekly, according to a schedule subject to the approval of the Principal

Qualifications & Skills

  • Position includes teaching 10th grade chemistry classes
  • Position may include working with students in advanced individual science projects in school’s SRP Program (Science Research Program) and may include teaching an advanced chemistry class in the future
  • Experience working with adolescents
  • Excellent organization and communication skills
  • Successful teaching experience (high school or higher education)
  • Familiarity with and understanding of practical uses of technology for instruction

Education

  • B.S. Degree with a major in Biology or Chemistry is required
  • Master's Degree in Biology or Chemistry or a Master of Science in Education is preferred
  • Evidence of continuing professional education through conferences, seminars, or professional associations is preferred

Compensation & Benefits

Salary range - $71,660. Commensurate with years of experience and level of success in the institutional advancement area, eligible for most benefits immediately.

Most benefits go into effect immediately. Participation in the 403 (b) occurs after one year of employment.

To Apply:

Interested applicants should submit a cover letter and resume by email to employment@regis.org. Qualified applicants will be contacted regarding next steps once all required documents have been submitted. Applications will be accepted until the position is filled.

Full ad here. Best wishes to those interested. 

Wednesday, April 17, 2024

The craziest hybrid sheep story you will hear today

Via Twitter and the Department of Justice: 

Defendant Worked to Traffic Marco Polo Sheep Parts from Kyrgyzstan, Clone Sheep, Illegally Inseminate Ewes to Create Hybrids and Traffic Rocky Mountain Bighorn Sheep Parts

A Montana man pleaded guilty today to two felony wildlife crimes – a conspiracy to violate the Lacey Act and substantively violating the Lacey Act – as part of an almost decade-long effort to create giant sheep hybrids in the United States with an aim to sell the species to captive hunting facilities.

Arthur “Jack” Schubarth, 80, of Vaughn, Montana, is the owner and operator of Sun River Enterprises LLC – also known as Schubarth Ranch – which is a 215-acre alternative livestock ranch in Vaughn. The Schubarth Ranch is engaged in the purchase, sale and breeding of “alternative livestock” such as mountain sheep, mountain goats and various ungulates. The primary market for Schubarth’s livestock is captive hunting operations, also known as shooting preserves or game ranches.

According to court documents, Schubarth conspired with at least five other individuals between 2013 and 2021 to create a larger hybrid species of sheep that would garner higher prices from shooting preserves. Schubarth brought parts of the largest sheep in the world, Marco Polo argali sheep (Ovis ammon polii), from Kyrgyzstan into the United States without declaring the importation. Average males can weigh more than 300 pounds with horns that span more than five feet. Marco Polo argali are native to the high elevations of the Pamir region of Central Asia. They are protected internationally by the Convention on International Trade in Endangered Species, domestically by the U.S. Endangered Species Act and are prohibited in the State of Montana to protect native sheep from disease and hybridization.

Schubarth sent genetic material from the argali parts to a lab to create cloned embryos. Schubarth then implanted the embryos in ewes on his ranch, resulting in a single, pure genetic male Marco Polo argali that he named “Montana Mountain King” or MMK.

Court documents explain that Schubarth worked with the other unnamed coconspirators to use MMK’s semen to artificially impregnate various other species of ewes – all of which were prohibited in Montana – and create hybrid animals. Their goal was to create a larger and more valuable species of sheep to sell to captive hunting facilities, primarily in Texas.

Presuming this is true, I can't feel very sorry for Mr. Schubarth. I do wonder if the people who were doing the cloning knew what he was doing, and if they knew it was illicit.  

WuXi in the NYT

There's an article in the New York Times about the BIOSECURE Act, and its impact with WuXi on the general pharmaceutical market. This is the only relevant portion (I feel): 

Last month, after a classified briefing with intelligence staff, the Senate homeland security committee advanced a bill by a vote of 11 to 1: It would bar companies from receiving government contracts for work with Wuxi, but would allow the companies to still obtain contracts for unrelated projects. Government contracts with drugmakers are generally limited, though they were worth billions of dollars in revenue to companies that responded to the Covid-19 pandemic.

The real question is 1) will a bill pass, and 2) what will the bill look like? If the Senate version looks like this (i.e. banning the government from working directly with WuXi, but not stopping pharma companies from working with WuXi), I suspect this is going to not be particularly impactful.

Tuesday, April 16, 2024

The 2024 Chemistry Faculty Jobs List: 548 research/teaching positions and 84 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 548 research/teaching positions and 82 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 18, 2023, the 2023 Chemistry Faculty Jobs List had 619 research/teaching positions and 80 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Monday, April 15, 2024

What's wrong with the new MLB uniforms?

That's a sweaty uniform. 
Credit: The Athletic
Also in this week's C&EN, this vitally important topic (article by Prachi Patel): 

Soon after the 2024 Major League Baseball (MLB) season started in March, sweat stains began to bloom along with spring flowers. In particular, sweat seemed to be soaking through the gray uniform jersey that team members wear when they play away from home, turning them visibly dark.

It shouldn’t surprise anyone, especially sports apparel companies, that athletes sweat. And synthetic sport performance fabrics, whether they’re intended for soccer, track, tennis, or lower-impact activities, are designed to provide temperature control and antibacterial properties to help keep their wearers comfortable and fresh.

In fact, 6 years’ worth of engineering went into the Nike Vapor Premier baseball uniforms, designed by Nike and manufactured by Easton, Pennsylvania–based Fanatics, according to the MLB. So what went wrong?

C&EN asked textile researchers to speculate, and they had fun doing it. “Textile structures are incredibly complex, and when you add chemical finishes, the degree of complexity multiplies,” says Juan Hinestroza, professor of fiber science and apparel design at Cornell University. So the answer to what possibly went wrong is “all of the above,” he says...

Because I'm a chemical manufacturing weirdo, this from the article makes the most sense to me. 

...Whatever the underlying chemical or material gaffe, the problem most likely stems from the uniforms’ complex manufacturing chain. Every MLB jersey and pair of pants is the product of multiple fiber and yarn producers, textile mills, and chemical suppliers spread across the world. To Henry Boyter, an expert on textiles and finishes and director of the Center for Environmentally Sustainable Textile and Apparel Businesses, it’s probably a quality control issue. “There is a large amount of testing that should have been done to ensure quality and that was probably not done,” he says. “We only know for sure that human wear trials were not completed, or ignored.”

I am rather surprised that these issues didn't turn up in their testing, or they ignored these issues. Either way, it doesn't seem like this is turning out well for MLB. I suspect that the second version of these uniforms will be better, but we shall see. 

Bloomberg: Metals prices are surging

Via Bloomberg: 

Aluminum and nickel surged on the London Metal Exchange as traders responded to new US and UK sanctions that banned deliveries of any Russian supplies produced after midnight on Friday.

The new restrictions, aimed at curbing President Vladimir Putin’s ability to fund his military, inject major uncertainties into metals markets that have already been reshaped in the aftermath of Russia’s invasion of Ukraine.

Aluminum jumped as much as 9.4%, the most since the current form of the contract was launched in 1987, while nickel rose as much as 8.8%. That suggests traders believe that removing one of the largest producers from the market will drive prices higher.

The rally is being fueled by “worries that the sanctions will reduce Russian flows to Western markets,” said Jia Zheng, head of trading and research at Shanghai Dongwu Jiuying Investment Management Co. “Any stimulation will be amplified amid an existing bullish backdrop.”

Still, there are also concerns over the prospect of a flood of old Russian metal — which is still permitted — getting dumped onto the LME.

I'm still learning the metals supply chains, so I don't think I have much to say about this, but it is still fascinating. 

Friday, April 12, 2024

Have a great weekend

I have one big thing to do today, and then I get to have a weekend. Here's hoping that you got your work done, and that you're having a great week. Have a good weekend and we'll see you on Monday. 

Moderna pauses its Kenyan manufacturing site

Via FiercePharma: 

Moderna made headlines in 2021 with a commitment to bringing more mRNA manufacturing capabilities to Africa, eventually landing on Kenya as the site of a $500 million plant project. Now, amid waning global vaccine demand, the company has hit pause on the endeavor.

The Spikevax maker is taking a step back to evaluate future demand for mRNA vaccines in Africa as it has not received any vaccine orders from the continent since 2022, Moderna said in a statement.

Cancelations of previous orders have stacked up to “more than $1 billion” in losses and write-downs, according to the mRNA specialist. The company said demand "has declined since the pandemic and is insufficient to support the viability of the factory planned in Kenya." 

Too bad - I was looking forward to the start of biopharma manufacturing in Africa. Here's hoping for brighter days. 

Thursday, April 11, 2024

Job posting: CMC reviewer, FDA, Silver Spring, MD

Via the Chemistry Discord (deadline is April 12):

The mission of the Center for Drug Evaluation and Research (CDER) is to perform an essential public health task by making sure that safe and effective drugs are available to improve the health of people in the United States. CDER regulates over-the-counter (OTC) and prescription drugs, including biological therapeutics and generic drugs.

The Office of Pharmaceutical Quality (OPQ) oversees and coordinates the overall regulation of pharmaceutical quality within CDER, including quality assessment of regulatory submission, manufacturing facility assessment, research, policy development, and surveillance of the quality of marketed pharmaceutical products.

The Offices of Product Quality Assessment (OPQA) III evaluate and assess product quality aspects over the product lifecycle for all types of human drug product applications, including Investigational New Drugs (INDs), Biologics Licensing Applications (BLAs), New Drug Applications (NDAs), Abbreviated New Drug Applications (ANDAs), and Active Pharmaceutical Ingredients (API) information supporting these applications, and make risk-informed recommendations on the approvability of such products and evaluates and assesses post-marketing activities for these drug products.

Duties/Responsibilities

As the Pharmaceutical Scientist, the incumbent is responsible for reviewing and evaluating comprehensive information and data on chemistry, formulation, manufacturing (including process monitoring and controls), biopharmaceutics (including drug release), as well as technical aspects of labeling and environmental impact submitted in Biologic License Agreements (BLAs), New Drug Applications (NDAs), Abbreviated New Drug Applications (ANDAs), and supplemental BLAs, NDAs, as appropriate. 

Full ad here. Best wishes to those interested. 

Wednesday, April 10, 2024

Drones as corporate intelligence tools

Via the New York Times, this interesting news about a plastics recycling plant: 

Then in November, Bleecker Street Research — a New York-based short-seller, an investment strategy that involves betting that a company’s stock price will fall — published a report asserting that the white pellets that had rolled off PureCycle’s line in June weren’t recycled from plastic waste. The short-sellers instead claimed that the company had simply run virgin polypropylene through the system as part of a demonstration run.

Mr. Olson said PureCycle hadn’t used consumer waste in the June 2023 run, but it hadn’t used virgin plastic, either. Instead it had used scrap known as “post industrial,” which is what’s left over from the manufacturing process and would otherwise go to a landfill, he said.

Bleecker Street also said it had flown heat-sensing drones over the facility and said it found few signs of commercial-scale activity. The firm also raised questions about the solvent PureCycle was using to break down the plastic, calling it “a nightmare concoction” that was difficult to manage.

PureCycle is now being sued by other investors who accuse the company of making false statements and misleading investors about its setbacks.

Mr. Olson declined to describe the solvent. Regulatory filings reviewed by The New York Times indicate that it is butane, a highly flammable gas, stored under pressure. The company’s filing described the risks of explosion, citing a “worst case scenario” that could cause second-degree burns a half-mile away, and said that to mitigate the risk the plant was equipped with sprinklers, gas detectors and alarms.

It is fascinating to see how these short selling firms work, and it's pretty clever to fly drones to find out more data (beats counting cars in a parking lot, I bet.)  

Tuesday, April 9, 2024

The 2024 Chemistry Faculty Jobs List: 547 research/teaching positions and 82 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 547 research/teaching positions and 82 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 11, 2023, the 2023 Chemistry Faculty Jobs List had 618 research/teaching positions and 77 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Job posting: visiting assistant professor, Point Loma Nazarene University, San Diego, CA

Via Twitter: 

PLNU is a Christian liberal arts university in the evangelical, Wesleyan tradition, offering quality undergraduate, graduate and professional programs. We provide higher education in a vibrant Christian environment where minds are engaged and challenged, character is modeled and formed, and service is an expression of faith. PLNU is an institution that is committed to reflecting the rich diversity of God’s kingdom. We therefore encourage applications from culturally and academically diverse faculty of the highest caliber, skilled and/or demonstrating great potential in the practice of teaching and scholarship. 

The Department of Chemistry is seeking candidates for a one year Visiting Professor of Chemistry. Responsibilities will begin mid-August 2024 and continue until mid-May, 2025. Academic rank will be based on degrees and experience, and the compensation level also depends upon the education and experience of the appointee. Review of applications will begin immediately and continue until the position is filled. The University encourages applications from a diverse group of applicants who support the mission of Point Loma Nazarene University.

Full ad here. Best wishes to those interested. 

Monday, April 8, 2024

C&EN: "Chemours completes financial probe"

In this week's C&EN, this news (article by Alexander H. Tullo):  

Chemours’s board of directors has completed an internal review of accounting irregularities that led to the ouster of CEO Mark Newman. In February, Newman was placed on leave pending the review. The probe found that $100 million in payments from Chemours to vendors due in the fourth quarter of 2023 were delayed until the first quarter of this year. Meanwhile, Chemours’s collection of $260 million in receivables due in the first quarter of this year was pushed to the fourth quarter of 2023. The moves boosted the company’s cash flow numbers. The audit found similar gaming in 2022 of $40 million in payments delayed and $175 million in receivables accelerated. Newman has resigned, but the audit may not close the book on the scandal. More than half a dozen law firms are preparing shareholder suits against the company. 

It is remarkable to me that Mr. Newman would decide to attempt this sort of accounting finagling, especially with a publicly traded company. 

Friday, April 5, 2024

Have a great weekend


Well, this has been a pretty chill week (by comparison) for me. Here's hoping that you've had a great week, and that you have a wonderful weekend. See you on Monday! 

Chemical drums found buried beneath a New York community park

Credit: Patch/Town of Oyster Bay
Via Patch: 

BETHPAGE, NY — Six 55-gallon chemical drums were found buried seven feet beneath Bethpage Community Park near the ball field and skatepark, the Town of Oyster Bay announced Wednesday. Supervisor Joseph Saladino renewed demands for Northrop Grumman to excavate all contaminated soils in the park.

"These chemical drums are encased in concrete coffins, which is highly uncommon according to environmental experts," the Town of Oyster Bay wrote.

The town called it a "graveyard of chemical drums."

A Grumman spokesperson said the company discovered several drums encased in concrete beneath a closed area of the park while conducting environmental remediation.

"We promptly notified NYSDEC and other relevant stakeholders and we are working with NYSDEC to assess and address this situation as quickly as possible," Grumman stated. "We remain committed to protecting the health and well-being of the community and to continuing our partnership with NYSDEC and other government regulators to address environmental conditions in the area."

It is really hard to imagine a world in which hazardous waste was not disposed of "properly."* It would be fascinating to know what the thought process around burying these drums were, and what potential other disposal methods there might have been years ago. 

*I'm loathe to credit federal legislation for business regulation, but it seems to me that a United States with RCRA is better than one without. 

Thursday, April 4, 2024

Job posting: Associate Principal Investigator, Toxinology, Battelle National Biodefense Institute, Frederick, MD

Via C&EN Jobs: 

BACKGROUND

The National Biodefense Analysis and Countermeasures Center (NBACC) is a one-of-a-kind facility dedicated to defending the nation against biological threats. Its work supports DHS and National biodefense preparedness planning, response, emerging threat characterization and bioforensic analyses. It is the first national laboratory created by DHS in response to biodefense gaps identified following the Amerithrax attacks of 2001 and has been operated by the Battelle National Biodefense Institute (BNBI) since 2006. Since its inception, NBACC and its staff have filled critical shortfalls in our scientific knowledge of biological agents needed to protect the public and defend the Nation from biological threats, whether naturally occurring, accidental, or deliberate and provided federal law enforcement with scientific data to support the investigation and attribution of biocrimes and protection of the US bioeconomy.

NBACC includes two centers: the National Bioforensic Analysis Center (NBFAC), which conducts the technical analyses in support of federal law enforcement investigations, and the National Biological Threat Characterization Center (NBTCC), which conducts experiments and studies to obtain data required for a better understanding of biological vulnerabilities and hazards. Together these centers offer a unique national resource for understanding the risks posed by biological agents and emerging technologies to inform biodefense policy and response planning and the operational capability to support the investigation, prosecution, and prevention of biocrimes and bioterrorism.

PRIMARY FUNCTION

Applies expertise in protein and peptide biochemistry in collaboration with a team of scientists in the NBTCC within the NBACC to perform Toxinology research that addresses specific questions of national significance in support of biodefense preparedness, response, and recovery. Areas of research include a range of topics related to the physical, biological, and/or pathological properties of toxin agents. Work will be performed in state-of-the-art laboratories. All facilities are fully staffed and equipped with a wide range of technologies required for biodefense and infectious disease research.

MINIMUM REQUIRED QUALIFICATIONS

  • Requires a PhD (or equivalent) in a scientific discipline or engineering, and a minimum of 2 years related experience.
  • Requires expertise in one or more of the following:
    • Heterologous protein expression, purification, and characterization.
    • Solid phase peptide and protein synthesis, purification, and characterization.
    • Cell-based toxicity and/or electrophysiological assays.

Full ad here. Best wishes to those interested. 

Wednesday, April 3, 2024

Tennessee General Assembly passes bill to ban atmospheric geoengineering

Via the BBC, this news:

Tennessee lawmakers have passed a bill banning the release of airborne chemicals that critics say is inspired by "chemtrails" conspiracy theories.

The bill forbids "intentional injection, release, or dispersion" of chemicals into the air.

It doesn't explicitly mention chemtrails, which conspiracy theorists believe are poisons spread by planes.

Instead it broadly prohibits "affecting temperature, weather, or the intensity of the sunlight".

The Republican-sponsored bill passed along party lines on Monday. If it is signed by Tennessee's governor, Republican Bill Lee, it will go into effect on 1 July.

Just to check, I verified that this was an actual bill that was actually debated and voted on (and passed) in the Tennessee General Assembly. This was not an April Fool's Joke.** Sadly, an amendment to add Sasquatch was voted down (I think.)

I wonder if Tennessee state representative Monty Fritts is concerned about other chemicals in the atmosphere? Surely he understands that, say, burning anything puts chemicals into the atmosphere that could affect temperature and weather?

*Here's another article from a different outlet showing the bill's movement through the general assembly.  

NSF: 1% fewer postdocs in academia in 2022

Via Science's Katie Langin, this news from NSF's Survey of Graduate Students and Postdoctorates in Science and Engineering: 

New data released by the U.S. National Science Foundation (NSF) reveal a sharp drop in the number of U.S. citizens working as postdocs, especially in the biological and biomedical sciences. The trend underscores concerns that the academic community is facing a postdoc shortage and that early-career scientists are increasingly favoring higher paid positions outside academia.

“It’s an unfortunate situation if domestic researchers are turning down postdoctoral positions because they’re inferior to positions in government or in industry,” says Tom Kimbis, executive director and CEO of the National Postdoctoral Association. “It’s not a situation that’s good for the country.”

The data come from NSF’s Survey of Graduate Students and Postdoctorates in Science and Engineering, which compiles employment data from academic institutions and estimates the number of STEM graduate students and postdocs across the country. According to the latest data release, 62,750 postdocs were employed at U.S. institutions in the fall of 2022, a 1% drop compared with the year before. But the trend diverges sharply by citizenship. From 2021 to 2022, the number of U.S. citizens and permanent residents working as postdocs dropped from 29,755 to 27,289. The 8% change is the largest year-to-year percentage-wise drop in the history of the survey, which has collected data since 1980. Meanwhile, the number of postdocs with temporary visas increased by 6%, from 33,573 to 35,461, about the same number as in 2020.

This is pretty interesting news. I'm genuinely interested to see if this trend continues, if it indeed is a trend. I'm generally skeptical of narratives that there is a "shortage" of postdocs. I think there is a perceived shortage of candidates from professors, or (another way to put it) the relative desirability of these postdocs has fallen. I have long asserted that postdocs are inferior goods, and this doesn't change my position.  

Tuesday, April 2, 2024

The 2024 Chemistry Faculty Jobs List: 546 research/teaching positions and 82 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 546 research/teaching positions and 82 teaching positions

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 4, 2023, the 2023 Chemistry Faculty Jobs List had 618 research/teaching positions and 75 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.