Some weeks cannot be busier. I hope you had a more peaceful week than me, but I'm fine. Hope you have a great weekend. See you on Monday!
Friday, October 4, 2024
C&EN: "Some tattoo inks in Europe contain banned pigments"
This news via C&EN's Krystal Vasquez:
A new study that analyzed 10 inks commonly used in Europe found that 9 of them were out of compliance with the European Union’s Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation (Analyst 2024, DOI: 10.1039/D4AN00793J).
Nine tattoo inks were found to be noncompliant with the European Union's Registration, Evaluation, Authorization, and Restriction of Chemicals regulation.
Under REACH, makers of tattoo inks and permanent makeup are required to list the products’ ingredients and reduce or eliminate compounds that could pose a risk to human or environmental health. For example, REACH recently banned two pigments common in blue and green inks, pigment green 7 and pigment blue 15:3, that the EU had also previously banned in hair color.
Of the nine noncompliant inks, the researchers determined that five had minor discrepancies; these inks did not contain any banned pigments, but their labels didn’t list all their ingredients. But four inks contained the banned pigment green 7, and two contained a variant of pigment blue 15. The researchers were unable to conclusively determine using their main method of analysis, Raman spectroscopy, whether the variant was the banned pigment blue 15:3.
Pretty interesting analysis - read the whole thing.
I guess I don't really understand why there is an expectation (even in Europe) that tattoo inks would follow EU chemical regulations. (Who enforces REACH in EU countries, anyway?) Do people looking for tattoos ask about this? Is there a German Tattoo Safety Agency?
Thursday, October 3, 2024
Job posting: Senior Scientist - Data Science, Analytical Research and Development (Onsite), Merck, Rahway, NJ
The Analytical Research and Development organization in Rahway, NJ is seeking a motivated Senior Scientist with technical expertise in data science and an ability to apply digital solutions to support our Company's pipeline of small molecule drugs, peptides, biologics, and vaccines. This role will allow the candidate to solve complex scientific challenges through application of data modeling, analysis, and visualization tools.
The successful candidate is expected to collaboratively work with synthetic, computational, and analytical scientists, understand their problem statements, and collaboratively implement and apply data science solutions. The candidate must be able to work proactively and independently and influence decisions and solutions spanning a wide diversity of problem statements across our Company Research Laboratories. The role will require the candidate to network across a range of departments and effectively collaborate with stakeholders. The candidate should exemplify positive ways of working which support diversity, inclusion, and a positive culture. The chosen candidate should have a demonstrated ability to publish and present research, including an established track record of interaction with the broader scientific community.
Full ad here. Best wishes to those interested.
Tuesday, October 1, 2024
The 2025 Chemistry Faculty Jobs List: 313 research/teaching positions and 26 teaching positions
The 2025 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 313 research/teaching positions and 26 teaching positions.
Want to help out? Here's a Google Form to enter positions.To see trending, go to Andrew Spaeth's visualization of previous years' list.
Don't forget to click on "load more" below the comment box for the full thread.
Are you having problems accessing the Google Sheet because of a Google Documents error? Email me at chemjobber@gmail.com and I will send you an Excel download of the latest sheet.
The Chemical Engineering Faculty Jobs List: 57 research/teaching positions and 11 teaching positions
The Chemical Engineering Faculty Jobs List (by Heather LeClerc and Daniyal Kiani) has 57 research/teaching positions and 11 teaching positions.
Monday, September 30, 2024
Sprinkler head causes major chemical release at BioLab trichloroisocyanuric acid facility in Conyers, GA
Ben Gray for the Atlanta Journal-Constitution |
A fire reignited Sunday at a chemical facility in Conyers, officials said, forcing the evacuations of local residents and leading to several road closures, including I-20.
Officials said the blaze reignited after being contained Sunday morning at BioLab on Old Covington Highway, the third such incident at the plant over the past seven years. Photos showed a massive plume of smoke in the sky that was visible from Hartsfield-Jackson International Airport — about 30 miles away.
The fire started about 5 a.m. after a sprinkler head malfunctioned and mixed with a water-reactive chemical and wiring at the plant, Rockdale County fire Chief Marian McDaniel said during a press conference Sunday. She said they were working on removing the material away from the water source at the facility and that the fire was contained to the roof. There were employees inside the plant but no injuries have been reported at this time.
“Once we can get that chemical out of the building and allow it to burn off we’ll be in a much better shape,” McDaniel said.
...Over her seven years with the fire department, McDaniel said it was the third such incident of “this magnitude,” in which a product mixed with water and started a chemical reaction at the plant. She said the most recent incident likely happened in 2021. The Georgia Emergency Management and Homeland Security Agency (GEMA) said it issued a shelter in place order on behalf of Rockdale’s emergency management agency, but no timetable has been provided as to when the area will be safe.
I am rather chagrined to note that I was very aware of the BioLab facility in Lake Charles having a release in 2020, but not aware that the Conyers facility had two such releases in 2020 as well. (The CSB writeup of the Conyers releases starts on page 72, and seems to also involve inadvertent water exposure.)
I am sure that the core problem is that "keep this stuff away from water" is harder than it seems, but I don't know, stopping major PR snafus and millions of dollars worth of preventable damage would seem to me to be important as well. I guess we'll have to read the new CSB report when it comes out.
C&EN: "The unfulfilled dream of drug reshoring"
In this week's C&EN, a very worthwhile article by Aayushi Pratap:
...In response, the federal government began funding start-ups and groups like the API Innovation Center in an effort to increase domestic production of small-molecule APIs and finished medicines. But industry watchers say the private sector generally isn’t following the government’s lead. While drug companies and contract manufacturers are putting huge sums into US plants for newer treatment modalities such as biologics, peptides, and antibody-drug conjugates (ADCs), traditional small-molecule APIs are getting little investment.
Hui-Yin “Harry” Li, president of Wilmington PharmaTech, a Delaware-based API maker, says some biotechnology and large pharmaceutical firms are attempting to move the drug ingredients they need back to the US, though not many have been successful. “This is largely due to the limited domestic manufacturing capacity,” he says. His company, which already had three facilities in Newark, Delaware, added a pilot plant in 2020 to manufacture highly potent APIs and ADCs. But building such plants in the US remains costly and time consuming, according to Li...
Lots of good quotes within. Read the whole thing!
Friday, September 27, 2024
Have a good weekend
Always an exciting week, especially a little before travel. Hope you had a good week, and a great weekend. See you on Monday.
Janitor death, chemical spill, science building shutdown alarms New Mexico Highlands University
Concerns about chemicals inside a New Mexico Highlands University science building have heightened following news of the death of a custodian who worked at the facility.Kathy Jenkins, president of the NMHU Faculty Association and professor of exercise physiology at the university, said in an interview with The Optic on Sept. 21 that the custodian, Martin Lujan, worked at Ivan Hilton Science and Technology Building.Ivan Hilton was closed by the city of Las Vegas on Sept. 3 after campus police responded to an initial report of a chemical spill at the building. According to a press release provided by the university on Tuesday, Ivan Hilton was closed on Sept. 3 “as a result of issues with the storage and maintenance of chemicals … and it currently remains closed.”Lujan passed away on Sept. 14.
Sounds like the chemicals initially involved may have included some biology fixatives (Carosafe, which is mostly propylene glycol and other organic compounds.)
...Assistant Professor Michael Remke, who teaches courses in forestry and natural resources, said he became ill after working at Ivan Hilton.
“I was going home sick with headaches, with respiratory distress and irritation after smelling fumes while sitting and working in my office,” Remke said on Sept. 19. He said that on Aug. 12 he made a complaint with human resources, filed a formal worker’s compensation claim and filed a claim with the school’s Environmental Health and Safety Office about the symptoms he was having.
Remke said his complaints were not addressed directly; however, a cold room at Ivan Hilton was taped off.
This cold room – a type of walk-in refrigerator on Ivan Hilton’s first floor – was being used to store chemicals, Remke said. He said it is not typical to store chemicals in a cold room and that such a space is more often used to store specimens and samples.
“I’m suspicious that … some of those chemicals were leaking, they were fuming, and the result was, as the cold room broke and heated up the fumes got really bad,” he said. “The fumes were seeping out of that environment (and) into the hallway on the first floor where they were impacting me in my office.”
Jenkins said she has received a list of chemicals that were found at Ivan Hilton. In an email to officials with AFT New Mexico, a union representing educators, as well as officials with National Education Association New Mexico, Jenkins said some of these chemicals include nitrobenzene, picric acid, radioactive thorium, cyanide and uncontained mercury.
I'm curious which chemicals were in the cold room. It sounds like Ivan Hilton had some chemical storage issues (which is probably true of 30% of American university science buildings.) My condolences to the family of Mr. Lujan.
Thursday, September 26, 2024
Job posting: Sr. Scientist - Chemistry Programs, Thermacell Repellents, Gainesville, FL
THE COMPANY: Thermacell Repellents, Inc. (TRI) is a privately held company with a mission to liberate people who love the outdoors from the harmful effects of insects. Founded in 1999 and based outside of Boston in Bedford, Massachusetts, Thermacell makes the world’s leading spatial mosquito repellent and targeted tick control solutions. Dedicated to delivering the best consumer experience, we have an ever-expanding product line for both adventure and home use. We aim to change the way people repel insects, and through disruptive innovation, strong distribution across multiple retail channels, and a global footprint, our base of users is growing rapidly.
TRI currently employs 125+ full time employees at our 4 locations: Bedford Massachusetts (Corporate HQ), Buford Georgia (Manufacturing & Distribution), Hampton FL (Science & Research Center).
POSITION PURPOSE: Thermacell is seeking a highly motivated Sr. Scientist – Chemistry Programs as part of the Science and Research team to lead all aspects of formula development, regulatory and other analytical chemistry testing, and provide technical expertise to other organizational areas. This new position will work at the Thermacell testing facility in Hampton, Florida under the daily supervision of and reporting to the Science Manager.
SKILLS REQUIRED:
- Doctor of Philosophy degree in chemistry preferred.
- Minimum 5-years of successful formulation and/or analytical chemistry experience - experience in pesticide/bioactive product formulation preferred.
- Proven ability to develop laboratory procedures and protocols compliant with global regulatory standards; Good Laboratory Practice (GLP) experience is preferred.
- Familiarity and proficiency with standard chemistry and laboratory equipment (e.g. GC/MS, analytical scales, etc.).
- Proven ability to plan, organize, problem solve, coordinate, and complete multiple tasks.
Full ad here. Best wishes to those interested.
Wednesday, September 25, 2024
There's a glut of old cocoa beans out there
Via the Financial Times, this important news:
A frantic hunt by chocolate manufacturers for high-grade cocoa has left a backlog of old, poor-quality beans lying in London’s warehouses, leading to a rare divergence in prices between the UK and the US.
Last month cocoa futures traded in New York rose strongly, peaking above $10,000 last week, while London prices fell, dipping below $6,400 earlier this month. Despite a sell-off in recent days, US prices are down just 3 per cent since the start of last month, compared with a 16 per cent drop for the UK contract.
Cocoa prices on both markets rallied strongly earlier this year, as poor weather and disease decimated crops in Ghana and Ivory Coast, where two-thirds of the world’s cocoa beans are grown, and as hedge funds piled into the market.
But the global shortage has led to a race among cocoa bean processors to secure high-quality beans, while shunning older varieties. Stocks of harvested beans are emptying, with US inventories at 15-year low and warehouses in London the lowest since 2021.
What is left in London is a “poisoned pill”, said Martijn Bron, who was global head of cocoa and chocolate trading for agricultural commodities giant Cargill until 2022.
The UK capital has historically been the market for large-scale purchasers of cocoa. But at the end of August more than one-quarter of the 54,650 metric tonnes of cocoa beans held in the London ICE exchange warehouses was more than three years old, according to exchange data. Moreover, almost 80 per cent of this older stock is bulk-stored beans grown in Cameroon, which is widely viewed in the industry as lower quality for making chocolate.
Never fear, chocolate manufacturers have solutions!:
...Bigger companies may add a small amount of cheaper Cameroonian cocoa — which, with a better colour than taste, is normally used to make powders rather than chocolate — into a blend, but they are constrained by their own protocols on quality, said Thornton. Smaller or private companies, on the other hand, “have more flexibility to cut costs”, she said.
“This will change the taste, but to be honest, with milk chocolate, by the time you add the sugar and milk, you can almost get away with anything,” said Thornton.
It would be really interesting to understand who buys the lowest quality cocoa beans for their chocolate.
You can buy hydrofluorocarbons on Facebook Marketplace?
The Biden administration has launched a new initiative to crack down on smugglers at US borders and ports. The concern isn’t drugs or counterfeit goods, though; it’s a refrigerant that’s also a dangerous greenhouse gas.
The US Environmental Protection Agency (EPA), Customs and Border Protection (CBP) and other agencies are arming themselves with new weapons — like AI tools that can pick out suspicious shipments — and rethinking ways of teaming up to combat the threat.
...The Biden administration made its first arrest under the law in March, charging a man in San Diego with smuggling HFCs allegedly bought in Mexico into the US. The indictment said Michael Hart concealed the refrigerants under a tarp and tools, then sold them on sites like Facebook Marketplace. The EPA has completed nine civil settlements linked to HFC importation in fiscal 2024, according to the agency.
Sounds like HFCs can fall off the back of a truck sometimes.
Tuesday, September 24, 2024
The 2025 Chemistry Faculty Jobs List: 288 research/teaching positions and 22 teaching positions
The 2025 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 288 research/teaching positions and 22 teaching positions.
Want to help out? Here's a Google Form to enter positions.To see trending, go to Andrew Spaeth's visualization of previous years' list.
Don't forget to click on "load more" below the comment box for the full thread.
Are you having problems accessing the Google Sheet because of a Google Documents error? Email me at chemjobber@gmail.com and I will send you an Excel download of the latest sheet.
The Chemical Engineering Faculty Jobs List: 47 research/teaching positions and 11 teaching positions
The Chemical Engineering Faculty Jobs List (by Heather LeClerc and Daniyal Kiani) has 47 research/teaching positions and 11 teaching positions.
Monday, September 23, 2024
BioCentury: Senate version of the BIOSECURE Act did not get added to NDAA
Via BioCentury's Steve Usdin, this update:
Despite a setback from the Senate Armed Services Committee, which declined to add the Biosecure Act to the bipartisan consensus draft of a must-pass defense bill, the legislation could still reach President Joe Biden’s desk this year.
Shares of contract development, research and manufacturing companies that would be directly affected by proposed restrictions on U.S. government contracting with Chinese biotech companies jumped Friday on the news that the Biosecure Act wasn’t included in a package of 93 amendments to the FY25 National Defense Authorization Act (NDAA).
I can't read the whole article (nor is this move corroborated anywhere), but Usdin is well known, so this is likely true. I expected this bill to slow once it hit the Senate, so this tracks.
C&EN: "Dow lowers expectations for the 3rd quarter"
In this week's C&EN (article by Alex Tullo):
Unexpected factors have forced Dow to lower its guidance for third-quarter performance. The company expects sales of $10.6 billion for the period, down from the $11.1 billion it forecast in July. Dow also predicts that earnings before taxes will be $1.3 billion. The company says it suffered an unplanned outage at one of its ethylene crackers in Texas in late July and has been hit by higher input costs in Europe, which are pinching profit margins. But Dow is getting a lift from higher selling prices and lower feedstock costs in North America.
It would be interesting to understand (maybe from the annual report) exactly how much of that $500 million adjustment could be attributed to the cracker being down - guessing the pressure to get it back up must be pretty high...
Friday, September 20, 2024
Have a good weekend
One of those weeks where it's mostly good news, I think. (We'll see.) Getting things done finally, and back into the groove (I hope.) Hope you had a good week, and that you'll have a great weekend. See you on Monday.
Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate showing up in fentanyl in the United States
Via the Los Angeles Times, this news:
An industrial chemical used in plastic products has been cropping up in illegal drugs from California to Maine, a sudden and puzzling shift in the drug supply that has alarmed health researchers.
Its name is bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, commonly abbreviated as BTMPS. The chemical is used in plastic for protection against ultraviolet rays, as well as for other commercial uses.
In an analysis released Monday, researchers from UCLA, the National Institute of Standards and Technology (NIST) and other academic institutions and harm reduction groups collected and tested more than 170 samples of drugs that had been sold as fentanyl in Los Angeles and Philadelphia this summer. They found roughly a quarter of the drugs contained BTMPS.
Researchers called it the most sudden change in the U.S. illegal drug supply in recent history, based on chemical prevalence. They found that BTMPS sometimes dramatically exceeded the amount of fentanyl in drug samples and, in some cases, had made up more than a third of the drug sample.
It was also a growing presence in fentanyl over the summer: In June, none of the L.A. fentanyl samples tested by the team contained BTMPS, the analysis found. By August, it was detected in 41% of them.
Here's the Medrxiv preprint. I don't think the material is particularly bad for you, but I suspect it's not particularly good for you either (especially if you smoke it.)
I know this is remarking on criminals being criminals, but it is distressing to me how impure drugs of abuse are, and how the whole supply chain seems to rely on "any old white powder" and so now they're using a random UV stabilizer to extend their product. Sad!
Thursday, September 19, 2024
Postdoctoral position: Postdoctoral Research Associate, Redox Flow Batteries and Membranes, Oak Ridge National Laboratories, Oak Ridge, TN
We are seeking a skilled postdoctoral candidate to focus on developing new redox flow batteries concepts. In this role, you will concentrate on materials and chemistries suited for long-duration energy storage (LDES), specifically: Assembly, testing, and structural design of redox flow batteries; Membrane processing and electrochemical evaluation within the flow battery setup, including characterizations of ion transport and thermal and mechanical properties; Development of electrochemical methods to evaluate failure modes in these systems.
This position is available within the Energy Storage and Conversion Group (ESCG) in the Chemical Sciences Division (X060) at the Physical Sciences Directorate (PSD) of Oak Ridge National Laboratory (ORNL). The selected candidate will engage in daily collaborations across the laboratory, contributing to novel scientific directions in partnership with the team and sponsoring organizations. This role supports ORNL’s mission to lead globally in energy storage science, addressing critical energy storage challenges vital for the economic and security interests of the United States.
Preferred Qualifications (Comprehensive but Not Exclusive):
- Experience with redox flow battery hardware build and test
- Experience with sulfur chemistry (e.g. Li-S or Na-S) is a plus
- Experience with CO2 electrochemical conversion is a plus
- Experience synthesizing organic and inorganic active materials for electrochemical energy storage
- Experience in synthesis and characterization of next-generation materials beyond Li-ion batteries
- Experience with sulfur electrode
- Experience applying interfacial coatings to optimize solid-solid and solid-liquid interfaces
- Experience in using advanced beamlines and analytical techniques (e.g., mass spectrometry, electron microscopy) to study material interfaces and mass transfer of membranes
Full ad here. Best wishes to those interested.
Wednesday, September 18, 2024
TIL "MOSFET"
Via the New York Times, this fascinating story about chips that can withstand high amounts of radiation on the upcoming NASA Europa Clipper mission:
People at NASA headquarters take deep breaths when the words “First Story” appear in their email. Late this spring, Curt Niebur, the lead scientist for flight programs, received such a message.
“You open that email right away,” Dr. Niebur said. “You read it, and then you reply, ‘Thank you for sharing,’ and then you bury your face in a pillow and you howl in terror.”
The matter prompting Dr. Niebur’s apprehension involved Europa Clipper, one of NASA’s most scientifically important missions. The agency’s science division created the “First Story” process to encourage science project staff members to communicate potentially bad news without fear of overreaction by leadership.
This news seemed exceptionally bad. If what Dr. Niebur was reading was true, Europa Clipper was cooked.
The story is the radiation-resistant chips known as MOSFETs, and how NASA dealt with the discovery that the chips did not work as well as thought without grounding the mission. For manufacturing nerds like me, it takes another article to learn that the German manufacturer of the chips is being mum about what the problem is:
On May 3, engineers at NASA’s Jet Propulsion Laboratory, in Pasadena, Calif., the primary manufacturer of the spacecraft, learned from a “non-NASA customer”* that vital, radiation-resistant chips failed when tested at radiation levels “significantly lower” than they were supposed to. Jordan Evans, the Europa Clipper project manager at the lab, presented the problem last month at a meeting of the Space Studies Board, a committee of the National Academies of Science that advises NASA.
The flawed chips in Europa Clipper are called metal-oxide-semiconductor field-effect transistors, or MOSFETs.
“We’re seeing some of these MOSFETs fail at lower radiation levels” than the prevailing environment around Europa, Shannon Fitzpatrick, the head of flight programs for NASA’s Planetary Science Division, said during a meeting of the Planetary Science Advisory Committee, a group of outside researchers who advise NASA, this week. She also said in the meeting that engineers had not yet solved the issue.
The chips currently in Europa Clipper are manufactured by Infineon Technologies, a German semiconductor firm. They are also used in military spacecraft. An Infineon spokesperson declined to comment on “actual or potential customers,” but said that the company has “stringent processes in place to ensure compliance with all relevant quality and performance standards for our products.”
It can't be fun to be an Infineon engineer for the last few months. Curious what the issue was.
*Amused to learn via Science that it was a classified non-NASA customer
Tuesday, September 17, 2024
The 2025 Chemistry Faculty Jobs List: 245 research/teaching positions and 18 teaching positions
The 2025 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 245 research/teaching positions and 18 teaching positions.
Want to help out? Here's a Google Form to enter positions.To see trending, go to Andrew Spaeth's visualization of previous years' list.
Don't forget to click on "load more" below the comment box for the full thread.
Are you having problems accessing the Google Sheet because of a Google Documents error? Email me at chemjobber@gmail.com and I will send you an Excel download of the latest sheet.
The Chemical Engineering Faculty Jobs List: 38 research/teaching positions and 11 teaching positions
The Chemical Engineering Faculty Jobs List (by Heather LeClerc and Daniyal Kiani) has 38 research/teaching positions and 11 teaching positions.
Monday, September 16, 2024
Student teaches her own chemistry class
Via Block Club Chicago, this rather remarkable story:
HUMBOLDT PARK — A week after their teacher left, the students were growing restless.
Despite promises that a permanent new teacher was coming, students in the sophomore-level chemistry class at Roberto Clemente Community Academy were sitting in their classroom with little to do. Though a substitute teacher was assigned to the room, the students quickly concluded that he didn’t know much about chemistry.
Carolina Carchi was struck by the reaction of one of her classmates: “They forgot about us.”
“When I heard that, this spark and passion grew in me,” Carolina said. She told herself: “No, you’re not going to be left out, they didn’t forget about you, and I’m going to be here to prove that.”
The following day, the 15-year-old got up in front of the class and began to teach her peers about the properties of liquids and solids and how to balance chemical equations.
Carolina went on to teach the class for two months during the winter of her sophomore year. A permanent teacher didn’t take over the classroom until the following fall.
I sense this staffing problem happened in either 2021 or 2022, which was a weirder time in the employment market. Nevertheless, students should have qualified teachers, and this was clearly not the case here.
Ms. Carchi is now a high school senior. Here's hoping she considers a career in either chemistry or teaching.
Consumer reports finds lead in cinnamon | FDA requests Congress to require food companies to test for lead
One dozen of 36 cinnamon products tested by a consumer group contained elevated levels of lead, according to a study released on Thursday that reinforced concerns about metals in foods after tainted cinnamon applesauce poisoned dozens of children last year.
The study, by Consumer Reports, documented levels that were far lower than the amounts discovered last year.
An agency spokeswoman said the F.D.A. had no authority to require companies to test final products for heavy metals, including foods consumed by babies and toddlers, who are particularly sensitive to the effects of lead. Their intestines absorb more lead, and their blood-brain barrier is still developing, Dr. Guilarte said.
The agency said it was asking Congress for the power to require food companies to do such testing and to review company records remotely whenever necessary.
I imagine this will increase the cost of cinnamon (and spices in general), but if it catches more lead in food, it might be worth it.