The Department of Protein Chemistry within the division of Large Molecule Drug Discovery in Genentech Research has an opening for a Senior or Principal Scientific Researcher to advance efforts on protein engineering of cell therapies. The Researcher will be responsible for discovery and implementation of new technologies and contributing to cross-functional teams. They will be expected to work independently, but also integrate closely with project teams, to generate and communicate results that drive project decisions. The successful candidate will also be expected to contribute to high-impact publications and presentations related to their responsibilities.Primary Responsibilities:Engineering, construct design, recombinant production, and in-cell production of protein components of cellular therapeutics. Examples include switch receptors, stimulus-responsive chimeric receptors, immunomodulatory cytokines, chemokine receptors, cellular logic circuits, context-dependent transcription factors, and other enhancements that enable the persistence, function, and phenotype of cell therapies. As a department representative on cross-functional project teams, the Researcher will work closely with Scientists and Researchers from across Research and Development to advance promising candidate cell therapies from concept to development handoff.
- PhD or Master’s degree with significant experience; post-doctoral experience demonstrating a breadth of knowledge is encouraged
- Expertise in biochemistry, chemical biology, enzymology, biophysics, structural biology, protein engineering, or a related discipline, with deep knowledge of protein structure and function