Is there a last bastion for those of us that want to “make stuff,” or will we forever run into the dilemma of choosing a field we like, but with less job security, or choosing a field we’d rather not do, but take content in being able to find a job later on?This is a difficult question. I should note that I really want to avoid the classic (and beat-to-death) "total synthesis is dead!" / "No, it's alive, well and the only way to show you're smart!" debate.
But to answer Chiral Jones' question, my answer is: no, there is no bastion. The global economic forces that seem to shape our lives will forever commoditize whatever can be commoditized. Unless the world we live in dramatically changes, it seems that if chemistry is simple, easy to communicate and profitable, there will always be a push to make things more profitable by substituting a cheaper chemist.
In regards to making stuff, I suppose it's the inorganic/materials folks will be the ones who are going to be 'making things' worry-free for the next twenty years or so. I'd like to think that organic chemistry and organic chemists will find a way to remove themselves from the commoditizing/outsourcing bullseye someday, but I don't think it's anytime soon.