Friday, June 3, 2011

Cheating: things oral exams can fix (but not scalable)

It's not fun to compare the salaries of doctors to chemists, but it is fun to compare the testing regimens to get into medical school versus graduate school. Also, it's terribly amusing to see what people will do to get around that testing. From Bruce Schneier comes a story of the cheater-in-the-middle:
Police allege he used a pinhole camera and wireless technology to transmit images of the questions on a computer screen back to his co-conspirator, Ruben, at the University of British Columbia.
Investigators believe Ruben then tricked three other students, who thought they were taking a multiple choice test for a job to be an MCAT tutor, into answering the questions.
The answers were then transmitted back by phone to Rezazadeh-Azar, as he continued on with the test in Victoria, police allege.
I would find it terribly amusing to attempt to cheat during an oral exam or your thesis defense. "The pKa of that compound? Hold on a sec..."

[Obviously, there are a heck of a lot more people trying to get into medical school than graduate school. Multiple choice tests are eminently scalable; oral exams are not.]  

Thursday, June 2, 2011

Interview feedback: an idea whose time has come?

Jim Austin at ScienceCareers points to a blogpost by Alison Vaillancourt on getting feedback from interviews:
It's a short essay; there's not a lot of advice there, and Vaillancourt really never answers the question. But two things make it worth reading. First, Vaillancourt describes the advice she long gave to people who had asked her whether they should provide feedback, before a recent experience altered her perspective: Don't tell losing candidates why they lost, she advised. Tell them why the winning candidate won. That would have worked for me: It accentuates positives, but it also would have told me what I needed to do to succeed in future interviews. 
Vaillancourt goes on to describe a situation where she did not do her best in an interview, and received some frank feedback on her performance.

I think this could be (and should be) done at most companies that hire chemists; I'm guessing that it would not add to the cost of an on-site interview to send an electronic form back to the non-hired candidate that gave some short feedback. Comments on perceived technical skill, social/'fit' issues with the group that you're going to work with, comments on communication could all be written up -- you could easily imagine a multiple-choice form that would be sent back to the candidate, along with the (sad) rejection phone call or letter.

It's my hope that companies will adopt this practice, but I'm not holding my breath. Sigh. 

Daily Pump Trap: 6/2/11 edition

Good morning! Between May 26 and June 1, there were 37 new positions posted on the ACS Careers website. Of these, 14 (38%) of these are academically connected and one (3%) is from Kelly Scientific.

Nice to see, I suppose: Eli Lilly is looking for a Ph.D. chemist to be a researcher in pharmaceutical solid state chemistry; they're looking for someone with 5+ years experience, academic or industrial. I'll bet the number of folks who have academic experience in organic solid-state chemistry would fit on a city bus comfortably.

This one's for the organickers: A postdoc position (2 years from degree) with Targacept, in Winston-Salem, NC. And...

Oh, dear: Proteostasis Therapeutics in Cambridge, MA is looking for a Ph.D. chemist to be a medicinal chemist. "PhD in organic chemistry or equivalent is required with 1-4 year post-doctoral/pharmaceutical experience for Scientist level and 3-8 years post-doctoral/pharmaceutical experience for Senior Scientist level."

In one sense, this is good, in that they're willing to consider folks with 3+ years postdoctoral experience. In another sense, this is bad, in that there are folks out there who have more than 3 years postdoc experience who haven't found positions. But that's to be expected with the 2008-201? employment recession in chemistry; it's just my hope that it doesn't become a hardened expectation to be hired.

Cambridge, again: Vertex is looking for a Ph.D. chemist to become a DMPK specialist. Some experience desired. 

SoCal, too: Hitachi (Irvine, CA) is looking for a Ph.D. chemist to be a member of a research team looking at polymer technology. Experience with biochemistry and polymer synthesis desired.

And points south: A PI is looking for a B.S. chemist to be a lab coordinator; experience with polymer and small molecule MS characterization is desired.

Wednesday, June 1, 2011

A helpful guide for your next research meeting


Process Wednesday: yeah, make up that sample any way you want.

I don't know about other chemists, but I know that I'm tempted to take samples from reactions and take a squirt of this and a squirt of that and chuck it into the ol' HPLC to monitor the reaction. Our mentor-by-literature, Neal Anderson, suggests that's not such a great idea with his guidelines for sample preparation for in-process controls:
  • Dilute sample properly. Dilution effectively slows or quenches reactions, allowing for reliable assays. 
  • Consistently measure volume of diluent. Use volumetric flasks to prepare dilutions. 
  • Accurately measure sample to be diluted. Deliver aliquot for dilution by a microliter syringe or volumetric pipette. Quickly weigh solid samples. If it is necessary to deliver quantities larger than those a pipette can accommodate, weigh the aliquot and dilute. 
  • Be consistent about order of dilution
  • Be sure that the sample is completely dissolved. This is particularly important if the sample purity is to be assessed. 
  • Note if dilution of the sample significantly changes the microenvironment of the analyte sample relative to the conditions of the surrounding solvent. For instance, dilution of a reaction aliquot into a HPLC mobile phase may change the pH of the mobile phase as the analyzed sample travels through the column, resulting in changes in retention times or peak shapes. 
This, of course, from Practical Process Research and Development, pg. 156. 

Doing things the right way every time is difficult and annoying sometimes. That being said, it's the only way of generating a consistent body of data. It's kind of funny how (even at this level) you I need to be reminded of that. 

Tuesday, May 31, 2011

A NIH program director takes on chemical employment issues

From this week's issue of Chemical and Engineering News comes an article by Britt Erickson that talks with John Schwab, a retiring program director at NIGMS that's been a champion of organic synthesis. What does he have to say to the graduate students that he's helping to fund?
Another change is the employment outlook for organic chemistry graduates. “In the past, chemistry departments could turn out as many synthetic chemists as they wanted because pharma hired people who were trained very deeply, albeit fairly narrowly, in organic synthesis,” Schwab says. “But these days pharma isn’t doing much hiring in the U.S., if any. There are relatively few jobs now for people who are trained in this way.” 
Chemistry departments must keep pace with the changing workforce and train their students broadly, Schwab stresses. “I think we need to be very much involved with our graduate students and postdocs to understand what their career goals are and to help them be realistic about preparation for the careers that will be there,” he says. Departments should support alternative career paths such as journalism, law, or policy, he points out. “I think it is going to be very important that people be flexible.” 
For students still interested in pharma careers, Schwab notes, related jobs are moving to East Asia and South Asia. With that in mind, he says, “an understanding of foreign cultures and foreign languages would be useful” when job hunting.
It could be frustrating and even galling to hear such things about your industry. That being said, I'm really glad that someone that's relatively influential understands the difficulty that synthetic organic chemistry graduates in the United States are facing. I think the question that we're faced with is how many high-profile Big Pharma synthetic jobs will still be around in the next ten years and will there be a boom time again for organic chemists in industry. Right now, the answer doesn't look good.

I suspect that Schwab is, like the rest of us, casting about for an answer to these problems. His answer, like many in our field, is that chemists now need to be trained 'broadly.' I admit that I find this answer to be unsatisfactory, probably for emotional reasons than anything else. If there is a better time (and a longer one) in a chemist's lifespan to gain expertise in chemistry than in graduate school, I would like to know when that time is. Seems to me that postdoctoral training is an excellent time to gain broader experience in law, policy or journalism.

[By the way -- seriously? Journalism, law or policy? Two of these three fields are suffering terribly right now, and I don't think the world needs more Ph.D.-bearing policy analysts. Call me crazy.]

Perhaps it's stupid optimism (and self-interested, too!), but I suspect that some level of chemical employment will continue in the United States, and it won't be necessary to add functional Mandarin or Hindi to your candidacy exam. (Hopefully.)

But it's important, as Schwab says, to look at things realistically. While I might quibble with his answers, I see Dr. Schwab as a kindred spirit in that he's clearly attempting to wrestle with the question of chemical employment. Thanks to him for his service, and best wishes for his retirement and good luck to all of us.

Monday, May 30, 2011

Day off today

Willamette National Cemetery (Photo credit: oregonlive.com)
It's Memorial Day in the United States, so it's a holiday for the blog. Back tomorrow with more commentary on chemical employment. 

Friday, May 27, 2011

Salary talk: what is the salary range of a computational chemist?

If this is your attitude towards computers (like mine),
you shouldn't be a computational chemist.
Photo credit: liberaldoomsayer.blogspot.com
Thanks to yesterday's graph about salaries, I've gotten to thinking about salary levels of non-bench chemists, specifically computational chemists and the cheminformatics folks. What's their pay range in comparison to bench chemists? Are they paid higher or lower?

In the environments I've worked in, there are traditionally a lot fewer computational folks than there are traditional synthetic chemists. (With the advent of the designer/synthesizer model that Derek Lowe was posting about yesterday, of course, that might change.) If I were a manager, I might be tempted to pay a computational chemist slightly more than a bench to attract a really good experienced modeler. It's not going to cost you that much more, and their results are going to be driving your science (if you let it.) They also serve, those who stand and compute. 

On the other hand, there sure are a lot of computational chemists out there, and supply-and-demand does drive these discussions. 

In other salary talk =, how much of a salary discount should you expect for working for a start-up versus an established company? (Have you ever noticed that a lot of small companies will refer to themselves as a start-up during salary negotiations, even though they've been around for 10 years?) 

Readers, you know the answers. Please comment freely. 

Thursday, May 26, 2011

Chart of the week: US household income distribution and some chemist salaries

Screenshot from NPR's Planet Money
I'm a big fan of thinking about the distribution of income amongst US households. The Tax Policy Center has put together a data set that divides the different percentiles; NPR's Planet Money team has graphed it.

I thought I would annotate the distribution with a few Chemjobber-esque notations. GlassDoor is pretty helpful with the Pfizer salary estimates. Also, I used the ACS starting salary study from 2009.

*There was one bold Pfizer VP that put their salary on GlassDoor, so take that data point with a fairly large grain of salt. Also, I'm guessing there are significant bonuses at that level. 

Daily Pump Trap, 5/26/11 edition

Good morning! Between May 24 and May 25, there were 15 new positions posted on the ACS Careers website. Of these, 4 (27%) are academically connected.

Uhh...: Genentech/Roche has something to say to you:
Who you are: You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies and where a job title is not considered the final definition of who you are, but the starting point. 
Actually, 'you' in this case is a B.S./M.S. process chemist with a good bit of experience, to be hired in at the associate principal scientist level in South San Francisco. Also, 'you' may be a B.S./M.S. medicinal chemist to be hired in at the principal scientist level in Nutley, NJ.

And one more: SuperGen (try saying that without adding the mental exclamation point) is looking for a B.S. medicinal chemist with at least 5 years experience. They're located in Salt Lake City, Utah.

Coffee is for closers: BASF is looking for a B.S. chemist to become a salesperson to the pharmaceutical industry in North America. (30% travel minimum.)

Alpharetta, GA: Arch Chemicals is looking for an M.S./Ph.D. analytical chemist with specialization in mass spectrometry and separations science.

Winston-Salem, NC: Targacept desires a Ph.D. analytical chemist with 5 years experience in the pharmaceutical industry, with an eye towards method development and CMC support.

Wednesday, May 25, 2011

Can't help it

Original photo: JD Hancock
Seeing people make cracks about Vertex's success with Incivek and how it made them a tempting target for Pfizer (I doubt this is actually true) made me think of this old classic film.*

*Needless to say, Vertex is not Bambi (have ya read Billion Dollar Molecule?) and Pfizer isn't Godzilla. Right? Right?

Process Wednesday: a drum is a living thing

From my browsings of Organic Process Research and Development comes a story too freaky not to mention:
The material in question was in a poly drum that contained approximately 20 kg of the aniline as an oil. After storing the unused portion of the 4-trifluoromethylaniline for 6 months in a warehouse, the material was brought into the laboratory to be sampled for further pilot work. This particular storage facility did not have temperature control, and no information was received that this material required special storage conditions. Upon examination of the drum contents, the material had formed a solid crystalline mass. [snip -- description of warming the drum in a 50°C air drier] 
With this unexpected result it was decided to examine the contents of the drum by NMR. The entire drum was brought into the laboratory and was placed in a large, empty, stainless steel tub as an added safety precaution. With the bung loose the contents were allowed to equilibrate for 5 h at which point some liquid was removed for analysis, and the bung was tightened. Approximately 15-30 min after sealing the drum it ruptured near the bottom and a white gas exited the drum with tremendous force. This gas quickly filled the entire laboratory, and fortunately the only occupant of the laboratory at the time was able to exit from a rear fire door without being affected. When the gas evolution ceased after 15 min, an investigation of the incident was immediately initiated.
The authors went on to describe their analyses of the remaining material; they believed that the material is a trimerized form of the trifluoromethylaniline. The offgassing, they believed, was the release of HF. Needless to say, someone could have been seriously injured if they had been close enough to the drum. The article has a number of intelligent cautionary things to say about storing of trifluoromethylaniline and its potential reactivity.

Personally, I like drums. They're really useful things and they contain plenty of material (or compound or solvent) for the typical chemist. But I am always a little wary around them because they are so large; it's not like you can pick a drum up and throw it out into the parking lot (which is not recommended for any number of reasons). But something being larger than you is always something to be treated with more respect, in my novice mind.

Tuesday, May 24, 2011

Are students willing to 'do what it takes' these days?

Do you know what love is, Kristel? It's finishing your degree,
and then working for 20k a year for a few years.
Photo credit: imdb.com
Thanks to a devoted reader, I'm treated to a CNN.com article about the difficulty in keeping STEM students in their STEM majors:
Undergraduates across the country are choosing to leave science, technology, engineering and math programs before they graduate with those degrees. Many students in those STEM fields struggle to complete their degrees in four years, or drop out, according to a 2010 University of California, Los Angeles, study. 
The study, conducted by UCLA's Higher Education Research Institute, found students in science, math and engineering take longer to complete their degrees than students who start out majoring in other fields. The study tracked thousands of students who entered college for the first time in 2004.
The article goes on to describe universities that have devoted some of their resources to changing their teaching style to attempt to stop some of this attrition. Good for them, I suppose.

But I'm amused to read a response in the comments (which, natural to any large website, is a treasure trove of headdesk), which I find typical of some people:
I have been a scientist in academia for almost 40 years and am at a top-ranked university.  From personal experience, most U.S. students who arrive on our doorstep wanting to major in STEM are not at the same level academically that they were 20 years ago and are not prepared to make the sacrifices it takes to succeed.  Foreign students are willing to work and sacrifice for their education, realizing that in these fields monetary success is often deferred.  Our youth in general are not trained to look at the long term but instead want 70K jobs when they graduate with a B.S.
I think it's silly to make the assertion that the kidz are not willing to defer gratification -- that's why they're in school, right? Because if it's Money Now they're after, waiting tables or selling mortgages insurance might be a better route. I think it is true that some students are looking hard at whether their time spent in school will lead them to a modicum of return; their expected return, I suppose, might be higher than some foreign students.

Ultimately, I suspect that it's true -- some people aren't willing to defer financial gratification. For them, STEM majors aren't a good idea (and they don't typically end up there to begin with.) But I suspect that many students are looking long and hard to see if their deferred gratification is actually that -- and finding out that the answer might be no.

Daily Pump Trap, 5/24/11 edition

Good morning! Between May 19 and May 23, there were 23 new positions posted on the ACS Careers website. Of these, 5 (22%) are academically connected and 1 (4%) is from our friends at Kelly Scientific Resources.

RTP!: DuPont weighs in with another Ph.D. chemist position, this time for a microelectronics research investigator. Inorganic background preferred, with "experience in crystalline Si cell production processes or materials."

Can't find what you want?: ATL International has been looking for nuclear forensic chemists for a while; in this position, you will "establish and maintain a quality assurance management system for laboratory operations that supports the requirements of an interagency national technical nuclear forensics program." Mass spec and other radiochemistry technique experience is desired. They're talking about 2000 (I'm guessing) qualified candidates here -- I wonder what's the best way to reach them?

Tamaqua, PA: Silberline Manufacturing Company is looking for a research scientist to perform work on pigments. You will be working on "Organic and Inorganic synthesis of functional adducts" and "Surface Chemistry of aluminum, glass, and other substrates to modify the color and/or rheological behavior of the materials". There's a nice little blurb about what you'll be responsible for, too: "Those hired will quickly take on responsibility for projects and will evolve to initiating and carrying out projects independently. We are looking for people who enjoy hands-on laboratory experimentation, teamwork, and also possess an entrepreneurial mindset." Good luck!

Zeroes!: Eastman Chemical Company in Kingsport, TN is looking for a Ph.D. chemist to be a process development researcher; 0-5 years experience is desired, along with a Ph.D. in organic chemistry. Gee -- I wonder if there are any of those?

Workin' for the man: FDA has come out with four postdoctoral positions in analytical chemistry in St. Louis, MO. Enjoy!

Hello, again: Our friends at Halcyon Molecular are back, looking for a M.S./Ph.D. chemist with experience in preparatory-scale chromatography; 5 years experience is desired. 

Monday, May 23, 2011

Not all Ph.D. chemists are managers, nor want to be

From this week's Chemical and Engineering News, a vaguely irritating letter:
While working toward a Ph.D. in physical chemistry, I noticed that many Ph.D.s in industry eventually moved out of the lab and into management (and perhaps picked up an M.B.A. along the way), hoping never to soil their hands with research again. Also, conversations with industry recruiters usually got around to the career ladder, with implications that after a few years one would move up and out of the lab. 
My love for the lab bench was the reason I chose a chemistry career to begin with, so this trend of moving from Ph.D. to off the lab bench was not for me. I decided to finish my studies with an M.S. degree. After five years, I still wound up managing a quality-control lab as chief chemist at an industrial plant, but I made sure to always have some bench time. 
Sure, it would have been nice to have a Dr. in front of my name when sending out Christmas cards, but if that meant not being able to train young chemical technicians in the lab and solve those chemical mysteries, then it would not be worth it. After a few downsizings, I wound up again running a small lab with one or two young chem techs, solving problems and enjoying getting my hands dirty at the lab bench. Too many Ph.D.s? Maybe, maybe not. I think one should have an idea of what they want to do with the degree that they are pursuing and not just get the degree and see what happens. 
Peter Doorley
Memphis
With all due respect to Mr. Doorley, some of this thinking is quite unfair. I don't know about other Ph.D. chemists, but I completed my degree because I wanted to finish something (for once in my life) and contribute to the chemical sciences, as opposed to finishing my degree so that I could someday sit in front of a computer (which seems to be the fate of the desk-bound chemist these days.)* Mr. Doorley also does not allow for the "up-or-out" mechanism at work for many Ph.D. chemists where they are expected to slowly move into leadership positions (whether they deserve them or not.)

It is also worth noting that training young chemists and solving chemical problems is the best part of being a senior chemist (of any education level.) While I am sure that there are those chemists who enjoy their time sitting in meetings and plotting the fates of many, I believe that there are many, many Ph.D. chemists who far prefer to influence younger generations and to solve key chemistry issues.

All of this to say that Mr. Doorley paints with a broad brush, and I feel unfairly besplattered.

*I'm going to be vaguely cynical here and make note that "I made sure to always have some bench time" is classic boss-speak for spending 2 hours in the lab performing a menial task that takes 30 minutes, all the while bothering your minions asking "Where are the pipettes?" and "Who moved my Gewurtztraminer apparatus?". 

Friday, May 20, 2011

Recommendation: bring a shotgun to the interview

From ACS Careers:
Brains for chemical biology - tenure track position
Job description The Donders Institute for Brain Cognition and behavior (DI) at Radboud University Nijmegen (Netherlands) is pleased to offer a tenure track position in the field of Chemical Biology. Chemical Biology is one of the top research priorities in Nijmegen and the DCN. This highly collaborative environment offers exceptional research opportunities to independent, motivated and gifted scientists. 
You are encouraged to launch your own independent research programme within the DI, which should be in line with one of the research themes listed below. Furthermore you are expected to publish in high-profile journals, attract your own external funding, and contribute to the teaching programmes of the Faculty of Science.
Within the DI’s chemical biology initiative one tenure track position is vacant on the following theme: 
Probing of cellular processes is highly relevant in the field of neuroscience. Chemical biology tools need to be constructed to image these processes on a cellular, and even molecular level. Smart viral delivery systems for genes that code for ion-specific proteins will thus enable the expression of channels and pumps in neuronal cells, which can be switched on and off with a tunable laser and thereby utilized in optogenetics studies.
I mean, sure, this could be the Netherland's most prominent universities with an excellent quality of life. Or, it could be a secret hideout of zombies and their human collaborators. Anybody that's advertising for braaaaaaaaains is subject to suspicion in times like these. 

Thursday, May 19, 2011

That's a lot of clams to be a salesperson

From LinkedIn, another data point in the "working for scientific equipment manufacturers" discussion in the comments of the plumber post:
My client is a highly respected, well known manufacturer of scientific instrumentation and consumables serving researchers at pharma and biotech companies, as well as scientists at academic and government research institutions. This client is looking to hire a San Francisco or San Diego based Sales Rep to cover CA, AZ, and NV. Overnight travel is estimated at around 30-50%. 
Requirements:
  • BS/BA degree in Chemistry (or related) is strongly preferred but applicable work experience could be substituted
  • Understanding of Organic Chemistry is preferred but not required 
  • Experience in sales or a customer facing role (Field Applications Scientist, Technical Specialist, etc)
  • Preference for capital equipment sales (equipment over 10k)
  • Excellent interpersonal, communication, and presentation skills
  • Ability and willingness to perform the required travel 
  • Ability and willingness to perform some of your own lead generation
Compensation:
The position offers a base salary + total comp of anywhere from 90-115k, depending on the base salary you receive and overall performance. Candidates seeking a total comp package at plan of up to 120k are encouraged to apply. The position also includes a car allowance, home office set-up, and complete benefits package. 
Uh, wow. That sounds like a lot of money*; of course, it is sales, where you're working your butt off and trying to interact with people. It is this latter item that I suspect most chemists just don't have the stomach for (I know I don't.) Best of luck to those who are interested (click through for contact info.)

*You could also argue that someone is exaggerating; that, of course, might be overly cynical.

Daily Pump Trap: 5/19/11 edition

Good morning! Between May 17 and May 18, there were 11 new positions posted on the ACS Careers website. Of these, 2 (18%) are academically connected and 1 (9%) is from Kelly Scientific Resources.

Safety: Arkema is looking for a senior product safety specialist; B.S. in chemistry and 5 years in product safety regulation desired.

Polymers: PPG Industries is looking for a Ph.D. chemist; polymer synthesis experience, the ability to supervise a technician (?) and the ability to pass a hair sample drug test (?!?) is desired.

Burlington!: Seventh Generation is looking for a B.S. chemist to become their research manager; 5 years in product development (hopefully in home cleaning products) is desired.

A broader look: Seems I'm doing more and more of these, as the ACS Careers feed starts drying up (and the Merck ads don't roll in.) Monster.com, Careerbuilder.com and Indeed.com show (respectively) 303, 709 and 4,268 positions for the search term "chemist." USAjobs.gov shows 88 positions for the search term "chemist." 

Wednesday, May 18, 2011

9 inch pipettes

A (long?) list of small, useful things (links):

Process Wednesday: no special solvent for you!

Want to buy that super-duper ultra pure solvent for your reaction in the lab? Our mentor-by-literature, Neal Anderson, says you're out of luck, bucko (from pg. 102 of  "Practical Process Research and Development"):
For initial laboratory investigations, whenever possible use solvents from bulk supplies that have been purchased for routine processing. Avoid special grades of solvents, such as HPLC-grade solvents, as processing may changes when reactions are run in bulk solvents, due to differing impurities and impurity levels.  
Using a higher grade of solvent may not be necessary. [snip] Once a special grade of solvent has been shown to be necessary, the purchase of the more costly material is readily justified. 
Well, drat. So unless you're willing to purchase that super-duper ultra pure grade by the rail car (hopefully you'll be buying it by the rail car, anyway), you're better off with the normal stuff.