What has to change is the economics of manufacturing in the USA. One way to do this is automated synthesis. A good example of a problem: How would one automate the synthesis of an OLED chemical like 1 MT of 8-hydroxyquinoline? This is an existing item of commerce, so entry into the market means taking share from someone else. You’ll probably have to best the market price by 10 % at minimum to induce someone to switch vendors.
The chemistry isn’t cutting edge, but the processing economics may be. This is an example of how entrepreneurialism can and should tackle manufacturing problems and gain a competitive edge. Since labor cost is a huge driver, find a way to shave off labor. An entrepreneur’s competitive edge may be process cost savings alone. You don’t have to wait for a scientific paradigm shift.Considering the synthetic details (that I've seen so far) include a Skraup reaction, I'm not quite sure how you might automate the process, but I'm guessing it could be done. Hmmmmmm.