|Credit: Laird, T. Org. Process Res. Dev., |
Dunn, P.J. Pharmaceutical Process Development
...From 2012 the policy on use of organic solvents has been changed to discourage scientists from using particular solvents and to encourage them to seek alternatives wherever possible; papers containing strongly undesirable solvents (e.g., benzene, carbon tetrachloride, chloroform, HMPA, carbon disulfide, etc.) will only be considered if accompanied by an analysis of alternatives or if a convincing justification for such use is presented.
The editors encourage all authors to consider these issues before submitting their papers to OPRD, and we warn that authors risk having papers rejected unless environmental impact and green chemistry principles are considered. (emphasis Laird's)He also provides a helpful table. Finally, he throws darts (legitimately!) at ethyl acetate:
The only quibble I have is that I prefer isopropyl acetate to ethyl acetate as an extraction solvent since the relatively high solubility of EtOAc in water (and water in EtOAc) means that the aqueous waste is contaminated with more organic material, thus making it harder to dispose of and also product could be lost in the aqueous layer!I'm vaguely surprised to see DMF and NMP on the list -- what's non-green about them?
UPDATE: Chemblogosphere pioneer milkshake has some recommended alternative solvents.