Details of the specific conditions must be thoroughly described before a process can be safely and reproducibly scaled up, especially by someone who did not develop the original process. Few chemists are naturally inclined to describe in detail the conditions that they used. The nonspecific descriptors ("groaners") listed [below] in Table 5.1 are not sufficient to allow for ready scale-up of most processes:
Added slowly, added dropwise (CJ's note: my personal favorite), to a dilute solution, added in portions, added to a cold solution, was run overnight, added at -78°C (was the temperature kept constant during the addition?*), with a slight exotherm, at room temperature (colder in England, hotter in the tropics*), excess reagent, vigorous agitation, worked up in the usual way, gave a white solid, sufficiently pure, yields given without consideration of product quality.Well, now you know -- so take a little more time writing up next time you throw it over the fence, hey?
*Anderson's comments, not CJ's.