"Running a reaction at or near room temperature offers many potential advantages for scale-up operations. First, operations on scale are extended if large masses of chemicals must be heated or cooled. Second, running under extreme levels of heating or cooling requires increases energy expenditures. Third, reactions run at an excessively high temperature may generate unacceptably high amounts of by-products, including colored impurities that may be difficult to remove from the product."You mean you can't just lift the reactor out of a silicone oil bath, spray it off with hexanes and drop it into an ice water bath? Darn.
"The rule of thumb is that increasing a reaction by 10°C will double the reaction rate. In practice, the reaction rate may decrease or even quadruple."
Wednesday, October 27, 2010
Process Wednesday: Reaction optimization tips
From Neal Anderson's "Practical Process Research and Development", page 170: