Thursday, August 17, 2023

Job posting: Principal Scientist, Chemistry, Bolt Biotherapeutics, Redwood City, California

Via C&EN Jobs: 

Bolt Biotherapeutics, located in Redwood City, CA, is a clinical-stage biotechnology company developing Boltbody™ Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics that have eliminated tumors following systemic administration in preclinical studies while also developing immunological memory, which may lead to more durable clinical responses for patients. This is a unique opportunity to join and build, with likeminded colleagues, a company that will transform the lives of individuals with cancers.

Key Responsibilities

  • Design, synthesis, purification, and characterization of novel immune agonists payloads for ISAC platform
  • Closely follow emerging results from SAR, pharmacological and ADME assays to contribute to the advancement of lead linker-payloads
  • Troubleshoot and optimize synthetic routes
  • Collaborate with chemists, biologists, and pharmacologists to interpret in vitro and in vivo

Job Requirements

  • Ph.D. in Chemistry or closely related field and a minimum of 8 years of industry experience
  • Aptitude for presentations at different levels, from project teams to senior leadership
  • Mentorship, development, and supervision of junior staff
  • Possesses strong medicinal chemistry bench skills and experience designing and executing multi-step syntheses

Posted salary: $150,000 - $195,000 a year. Best wishes to those interested. 


  1. I read on a Blind that a 300K salary in the bay area is worth 90K in a LCOL. Is that a fair statement?

  2. Why does everyone want to call their company "bolt"?

  3. 150-200k salary is low for Bay Area+PhD+8 YOE. There are tech companies there hiring fresh college grads in that range.


looks like Blogger doesn't work with anonymous comments from Chrome browsers at the moment - works in Microsoft Edge, or from Chrome with a Blogger account - sorry! CJ 3/21/20