Need a recipe for an organic transformation? Aldehyde to oxime to nitrile not working? Need to add three carbons to an acid to make the 1,4-keto aldehyde? Since the mid-1970’s, I have been building a database of organic transformations, from reducing a ketone in the presence of an aldehyde (and vice versa) to methods for isoxazole synthesis. Now that I have retired from teaching, I can offer an inexpensive search service. Just email me the search, we will discuss back and forth until it is clear exactly what is wanted, and I will send you brief descriptions with references. The cost? $100 search, or $2000/25 searches in a year, $10,000/150 searches in a year, payable ahead of time. I will only charge for the search if the customer is satisfied. This is more economical than SciFinder, and more efficient, since the results are intelligently filtered.He then gives his cell phone number, which I was a little bit surprised at.
What about those two searches?
Aldehyde to nitrile, other than oxime dehydration:
Dimethylhydrazine + propylene oxide: Synthesis 1979: 301
Ammonia + iodine: JOC 68: 1158; TL 42: 1103; 49: 2213
Ammonia + other oxidant: Syn Comm 1979: 529; Synlett 2003: 143; 2003: 262
Oxidation of hydrazone: JACS 122: 4526; JOC 61: 1159; TL 29: 811; 34: 141; 39: 2009; 47: 8969
With NaN3/SiCl4: TL 36: 2639
From lactol, via azide: ACIE 33: 751
By free radical fragmentation/cyanation: JOC 65: 3961
Acid chloride to 1,4-keto aldehyde: a-silyloxy allyltrimethyl silane/TiCl4, JOC 53: 2551 (1978)
If you would like to know more, send me an email (CJ's note: taberdf -at- udel/dot/edu), or give me a call.
I can't say that I'm completely shocked at the existence of such a service, but I think that it is interesting that he is monetizing his personal list of references - not a terrible idea, really. Also, I think that he says that it's more economical than SciFinder (true!) and more intelligently filtered (definitely true.) I wonder what other literature searchers/consultants charge, and how it compares.
I am interested to see if his price point is reasonable and who will use it -- industrial researchers? I might use it for work, but it'll be one-off sorts of things. I wonder if his prices will be negotiable? Hmmmm.