I have other posts scheduled for today, but they're being written. I want to take a moment and point you to See Arr Oh's project with katmatcher, BRSM and Organometallica called "Blog Syn". They're looking at an interesting Fe/S-catalyzed benzimidazole synthesis that was recently published in J. Am. Chem. Soc.
After 3 separate people (BRSM, katmatcher and OM) in 3 separate laboratories have done the chemistry in the paper, they've labeled it "moderately reproducible."
It'll be interesting to see how they verbally describe papers from here on out. I suggest a few other terms to be introduced, including "totally sketchball", "rock solid" and the ever-popular "This reaction is so rugged my 90-year-old grandma could run it."
I have 3 things to say about it:
- This is awesome. It's really important and good for the wider chemistry community. More people should be telling each other their results like this. It's beautifully documented, too.
- Vinylogous is right; this needs established PI support for it to thrive as well as it should. While there are definitely future (and current!) assistant professors reading about this and thinking about it, I think that a couple of brave associate and full professors throwing their weight behind this now would be fantastic.
- I think that this would be a perfect project for senior theses (and maybe as part of a candidacy exam?)
Readers, please go over there, read and comment. Also, thoughts on how to make this better? Got a procedure to vet?