The Cardiovascular Metabolic and Endocrine (CVMED) Design Chemist provides scientific leadership in the medicinal chemistry group aligned to the CVMED Research Unit (CVMED RU). This individual is responsible for leading the medicinal chemistry effort on 2-3 projects within the CVMED RU in collaboration with the CVMED Biology Group and synthetic chemistry.
An outward looking focus is important given the network of resources within World Wide Medicinal Chemistry (WWMC) that will be leveraged to advance CVMED programs. These include, but are not limited to, structural biology, computational chemistry, chemical biology, drug safety and drug metabolism.
Collaboration with additional external academic collaborators will be necessary to advance the CVMED portfolio and drive discipline excellence within the CVMED RU and WWMC. This design chemist will be responsible for all of the molecular design for their assigned programs and will be directly accountable for their designs advancing projects from exploratory stages to delivery of clinical candidates that survive to positive proof of concept (POC). The design chemist is also accountable for working with synthetic chemists to ensure that design and synthetic excellence drive appropriate selection of target compounds and speed to FIH. (emphasis CJ's) The design chemist is accountable for driving a strong scientific agenda wherein internal research capabilities are integrated with a broader research network to drive new thinking and capabilities in design.
Qualifications Doctoral level degree, or equivalent with at least 5 years experience in the
pharmaceutical industry and 3 years experience leading design efforts on a project.
Strong working knowledge and track record of delivery in drug discovery - from exploratory chemistry to clinical testing.
The role is located in Cambridge, Mass and will require visits to the Groton Connecticut sites for face to face meetings. The frequency of these visits will be 6-12 times per year.