Monday, June 6, 2016

I'm not crazy, am I?

Credit: Doug Taber, Organic Chemistry Highlights
I like reading Doug Taber's "Organic Chemistry Highlights" every week. Weird question - is there anything weird about today's 2nd synthetic scheme?*

*there isn't some sort of notation that I'm not familiar with, is there?
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5 comments:

  1. bad wolfJune 6, 2016 at 2:13 PM

    I haven't seen the Sigma-for-TMS before, either, if that's what you mean. The original paper just has it as an R group. Taber's personal code or is this catching on somewhere?

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  2. HapJune 6, 2016 at 3:31 PM

    I think I've seen sigma for silyl group before but not often - maybe he used it because you can't fit TMS easily in that spot in the structure.

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  3. AnonymousJune 6, 2016 at 4:28 PM

    I wonder if was a simply space issue as TMS blocked ring bonds, if so assume text or scheme legend in paper defined it that way since R is classically used for alkyl and carbon fragments. Alternatively I associate Sigma with "Sum of" math symbol therefore not clear what else would be the besides TMS but this could be representing more than one protecting group is observed?

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  4. AnonymousJune 7, 2016 at 12:00 AM

    I'm all for it; some of the silyl protecting groups can get rather ridiculous (TBDPSCl anyone?), so abbreviations are always appreciated as long as they're defined.

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  5. Nick KJune 8, 2016 at 1:45 AM

    It's rare, but I've seen the sigma symbol used as a shorthand for TMS.

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looks like Blogger doesn't work with anonymous comments from Chrome browsers at the moment - works in Microsoft Edge, or from Chrome with a Blogger account - sorry! CJ 3/21/20

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