Monday, June 6, 2016

I'm not crazy, am I?

Credit: Doug Taber, Organic Chemistry Highlights
I like reading Doug Taber's "Organic Chemistry Highlights" every week. Weird question - is there anything weird about today's 2nd synthetic scheme?*

*there isn't some sort of notation that I'm not familiar with, is there?

5 comments:

  1. I haven't seen the Sigma-for-TMS before, either, if that's what you mean. The original paper just has it as an R group. Taber's personal code or is this catching on somewhere?

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  2. I think I've seen sigma for silyl group before but not often - maybe he used it because you can't fit TMS easily in that spot in the structure.

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  3. I wonder if was a simply space issue as TMS blocked ring bonds, if so assume text or scheme legend in paper defined it that way since R is classically used for alkyl and carbon fragments. Alternatively I associate Sigma with "Sum of" math symbol therefore not clear what else would be the besides TMS but this could be representing more than one protecting group is observed?

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  4. I'm all for it; some of the silyl protecting groups can get rather ridiculous (TBDPSCl anyone?), so abbreviations are always appreciated as long as they're defined.

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  5. It's rare, but I've seen the sigma symbol used as a shorthand for TMS.

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