There are a number of bioorthogonal reactions which remain unexplored in the area of Antibody-Drug Conjugates. Studying a panel of unnatural amino acids will expand our understanding of the structure-activity-relationship (SAR) of these amino acids and their corresponding tRNA synthetase, thereby expanding MedImmune’s capabilities to design the next generation of ADCs or other protein conjugates.Interested? E-mail thompsonpam-at-medimmune/dot/com (note spam-proofing)
The summer intern will synthesize and purify a library unnatural amino acids and fully characterize them by LC-MS, 1H NMR, and 13C NMR. These amino acids will then be analyzed for their incorporation efficiency during protein expression using a high throughput method developed at MedImmune.
At the end of the internship, the student will prepare and present a poster at the intern science fair. In addition, the student will present his/her research during our group meeting.
This paid internship is open to both undergraduate and graduate students. Preferably, the student would have some experience in synthetic chemistry beyond O-Chem lab.
Wednesday, April 29, 2015
Internship opportunity: MedImmune, Gaithersburg, MD
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