Tuesday, April 21, 2015

Job posting: experienced computational chemist, AstraZeneca, Waltham, MA

From the inbox: 
We are currently recruiting a highly qualified computational chemist who will be joining our fast-pace multidisciplinary oncology team. The successful candidate will support project teams from target identification through lead optimization. The candidate is expected to have a degree of independence and proven record of excellence in a number of computational chemistry and cheminformatics techniques to assist in the identification and advancement of small-molecule drug discovery programmes. The qualified candidate will be creative, detail-oriented and a problem solver able to work collaboratively with a passion for drug discovery. 
The candidate will work closely with chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties. The work will include helping project teams analyse, interpret, and visualize biological data, and communicate these results. Additional responsibilities may involve using modeling and bioinformatics tools to provide druggability assessment for novel target classes, predicting novel druggable sites for known target classes, or mining databases for chemical starting points. The candidate will be expected to plan, write and publish high quality scientific papers with original results. 
Requirements: 
* A PhD (or equivalent experience) in computational chemistry, biophysics, or a related field, and 5 years industry experience
* Sound understanding of physical and medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
* Experience in structure-based drug design (e.g., docking and scoring, virtual screening, library design, homology modeling)
* Familiarity with chemoinformatics and bioinformatics tools for database similarity searching, pharmacophore modeling, QSAR modeling, and identification and analysis of protein binding sites
* Experience with in silico predictive methods for the improvement of physico-chemical and ADMET characteristics
* Strong programming/scripting capability (e.g., python, perl, OEChem toolkit, C++) is desirable
* Excellent written and oral communication skills and the ability to communicate complex information clearly
* Ability to work effectively within collaborative, multi-disciplinary teams
Link here. Best wishes to those interested.  

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