Monday, August 20, 2012

Dear Dave Sommers: You Are Wrong

For those of you who have had some basic medchem (as I have had, and no more), I thought you would enjoy this little tidbit. It's kinda funny when people get things exactly backwards.

(Incidentally, here's a wonderful refutation of this graphic by SkepticRD, a registered dietitian.) 


  1. I looked up data on the fate of benzoate in the body: it is rapidly eliminated in the urine.

    Even at high doses there appears to be no tissue accumulation. It forms a glucuronide and also a glycine conjugate (hippuric acid), which is the main excreted form in man, rabbit and rat.

    Your body makes large amounts of benzoate from digestion of phenylalanine residues. Urine can contain up to 10% hippuric acid and benzoyl-glucuronic acid.

    most info came from www(dot)inchem(dot)org/documents/jecfa/jecmono/v05je06(dot)htm

  2. An organic lab text I used as a TA in the last century had an expt that asked the student drink a PhCOOH soln, then isolate the hippurate conjugate from urine. Students not up for that, so I opted out.